follistatin Antibody (D-12): sc-271502
- follistatin Antibody (D-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 231-344 mapping at the C-terminus of follistatin of human origin
- recommended for detection of follistatin isoforms 1-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for follistatin Antibody (D-12) for WB applications. These reagents are now offered in bundles with follistatin Antibody (D-12) (see ordering information below).
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follistatin Antibody (D-12) is a mouse monoclonal IgG2a antibody that detects follistatin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Follistatin is a high-affinity binding protein that plays a crucial role in regulating the activity of activin, a member of the transforming growth factor-beta (TGF-beta) superfamily, which is essential for various physiological processes, including the regulation of follicle-stimulating hormone (FSH) release. Follistatin is primarily located in the extracellular space, where follistatin acts as a key modulator of autocrine and paracrine signaling pathways, influencing reproductive functions and other biological processes. By binding to activin, follistatin not only inhibits activin activity but also helps maintain the balance of FSH secretion from the pituitary gland, which is vital for normal reproductive health. Follistatin′s ability to interact with other proteins in the TGF-beta superfamily underscores follistatin′s importance in cellular signaling and homeostasis, making anti-follistatin antibody (D-12) an invaluable tool for researchers studying reproductive biology and related fields.
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follistatin Antibody (D-12) References:
- Follistatin/activin-binding protein. | Robertson, DM. 1992. Trends Endocrinol Metab. 3: 65-8. PMID: 18407081
- Circulating follistatin in relation to energy metabolism. | Hansen, JS. and Plomgaard, P. 2016. Mol Cell Endocrinol. 433: 87-93. PMID: 27264073
- Impaired Follistatin Secretion in Cirrhosis. | Rinnov, AR., et al. 2016. J Clin Endocrinol Metab. 101: 3395-400. PMID: 27399349
- The emerging role of follistatin under stresses and its implications in diseases. | Zhang, L., et al. 2018. Gene. 639: 111-116. PMID: 29020616
- Follistatin inactivation improves glucose tolerance. | Leong, I. 2018. Nat Rev Endocrinol. 14: 439. PMID: 29946128
- Activins, follistatin and immunoregulation in the epididymis. | Wijayarathna, R. and Hedger, MP. 2019. Andrology. 7: 703-711. PMID: 31322318
- Follistatin and follistatin-like 3 in metabolic disorders. | Bielka, W., et al. 2023. Prostaglandins Other Lipid Mediat. 169: 106785. PMID: 37739334
- Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons. | Jiang, BC., et al. 2024. Sci Transl Med. 16: eadi1564. PMID: 39413164
- Follistatin-mediated vascular protection via inhibition of activin A in essential and secondary hypertension. | Mukohda, M., et al. 2024. Hypertens Res. 47: 3494-3495. PMID: 39420092
- Follistatin: a multifunctional regulatory protein. | Phillips, DJ. and de Kretser, DM. 1998. Front Neuroendocrinol. 19: 287-322. PMID: 9799587
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
follistatin Antibody (D-12) | sc-271502 | 200 µg/ml | $316.00 | |||
follistatin Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-540242 | 200 µg Ab; 10 µg BP | $354.00 | |||
follistatin Antibody (D-12): m-IgG2a BP-HRP Bundle | sc-546875 | 200 µg Ab; 10 µg BP | $354.00 |