FNDC3B Antibody (B-1): sc-393997

FNDC3B Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects FNDC3B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FNDC3B antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FNDC3B, also known as factor for adipocyte differentiation 104 or HCV NS5A-binding protein 37, plays a critical role in adipogenesis, the process by which pre-adipocytes differentiate into mature adipocytes. This process is particularly significant due to the involvement of adipocytes in metabolic disorders such as obesity and type II diabetes, as adipocytes secrete hormones and bioactive peptides that influence various physiological functions, including hemostasis, angiogenesis, and energy balance. FNDC3B is expressed during the early stages of adipogenesis and is a 1,204 amino acid protein characterized by the presence of nine fibronectin type-III domains. Notably, FNDC3B-deficient mice exhibit a lethal phenotype within one day of birth, underscoring FNDC3B′s essential role in survival and development. Studies have shown that mouse embryonic fibroblasts lacking FNDC3B function demonstrate impaired stress fiber formation, indicating FNDC3B′s involvement in critical cellular processes such as proliferation, adhesion, spreading, and migration.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FNDC3B Antibody (B-1) References:

1. The molecular control of adipogenesis, with special reference to lymphatic pathology.  |  Rosen, ED. 2002. Ann N Y Acad Sci. 979: 143-58; discussion 188-96. PMID: 12543724
2. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis.  |  Tominaga, K., et al. 2004. FEBS Lett. 577: 49-54. PMID: 15527760
3. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation.  |  Tominaga, K., et al. 2004. J Cell Sci. 117: 6217-26. PMID: 15564382
4. Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome.  |  Ailhaud, G. 2006. C R Biol. 329: 570-7; discussion 653-5. PMID: 16860275
5. [Characterization of novel genes regulating adipocyte differentiation].  |  Johmura, Y. 2007. Yakugaku Zasshi. 127: 135-42. PMID: 17202794
6. A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion.  |  Hishida, T., et al. 2008. FEBS J. 275: 5576-88. PMID: 18959745
7. Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.  |  Szeliga, M., et al. 2009. Glia. 57: 1014-23. PMID: 19062176
8. Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration.  |  Nishizuka, M., et al. 2009. Exp Cell Res. 315: 809-19. PMID: 19138685
9. Understanding adipocyte differentiation.  |  Gregoire, FM., et al. 1998. Physiol Rev. 78: 783-809. PMID: 9674695

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FNDC3B Antibody (B-1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-FNDC3B Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FNDC3B Antibody (B-1) Specifications

Alternate Product Name: FNDC3B

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 6-21

Epitope Target: FNDC3B

Epitope Species: human

Product Reactivity/Detection: FNDC3B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for FNDC3B Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin