FNBP1 Antibody (C-9): sc-515414
- FNBP1 Antibody (C-9) is a mouse monoclonal IgG1 FNBP1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 146-163 within an internal region of FNBP1 of human origin
- FNBP1 Antibody (C-9) is recommended for detection of FNBP1 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-FNBP1 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for FNBP1 Antibody (C-9) for WB applications. These reagents are now offered in bundles with FNBP1 Antibody (C-9) (see ordering information below).
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FNBP1 Antibody (C-9) is a mouse monoclonal IgG1 antibody that detects FNBP1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FNBP1 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FNBP1, also known as formin binding protein 1, FBP17, or KIAA0554, is a 617 amino acid protein that plays a vital role in cellular processes by localizing to key areas within the cell, such as the cytoplasm, cytoskeleton, lysosome, and cell cortex. This localization is crucial for linking the actin cytoskeleton with Rho 7 signaling, which is essential for membrane tubulation and cytoskeletal reorganization during endocytosis. FNBP1 enhances actin polymerization and promotes membrane invagination, facilitating the formation of tubules necessary for various cellular activities. Notably, FNBP1 exists as four alternatively spliced isoforms and is expressed at high levels in the respiratory, reproductive, and urinary systems, as well as in brown adipose tissue and epithelial cells of the gastrointestinal tract. Chromosomal aberrations in the FNBP1 gene have been associated with acute leukemias, indicating a potential role for defective FNBP1 in carcinogenesis, making FNBP1 a significant target for research in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FNBP1 Antibody (C-9) References:
- The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. | Fuchs, U., et al. 2001. Proc Natl Acad Sci U S A. 98: 8756-61. PMID: 11438682
- Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. | Fujita, H., et al. 2002. J Biol Chem. 277: 45428-34. PMID: 12244061
- FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. | Katoh, M. and Katoh, M. 2003. Int J Mol Med. 11: 791-7. PMID: 12736724
- The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. | Fuchs, U., et al. 2003. FEBS Lett. 554: 10-6. PMID: 14596906
- A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. | Kamioka, Y., et al. 2004. J Biol Chem. 279: 40091-9. PMID: 15252009
- Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL. | Qian, J., et al. 2006. Cell Signal. 18: 1327-37. PMID: 16318909
- Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. | Tsujita, K., et al. 2006. J Cell Biol. 172: 269-79. PMID: 16418535
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. | Nagase, T., et al. 1998. DNA Res. 5: 31-9. PMID: 9628581
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FNBP1 Antibody (C-9) | sc-515414 | 200 µg/ml | $322.00 | |||
FNBP1 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-528035 | 200 µg Ab; 10 µg BP | $361.00 | |||
FNBP1 Antibody (C-9): m-IgG1 BP-HRP Bundle | sc-533408 | 200 µg Ab; 20 µg BP | $361.00 | |||
FNBP1 Antibody (C-9) AC | sc-515414 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FNBP1 Antibody (C-9) HRP | sc-515414 HRP | 200 µg/ml | $322.00 | |||
FNBP1 Antibody (C-9) FITC | sc-515414 FITC | 200 µg/ml | $336.00 | |||
FNBP1 Antibody (C-9) PE | sc-515414 PE | 200 µg/ml | $349.00 | |||
FNBP1 Antibody (C-9) Alexa Fluor® 488 | sc-515414 AF488 | 200 µg/ml | $364.00 | |||
FNBP1 Antibody (C-9) Alexa Fluor® 546 | sc-515414 AF546 | 200 µg/ml | $364.00 | |||
FNBP1 Antibody (C-9) Alexa Fluor® 594 | sc-515414 AF594 | 200 µg/ml | $364.00 | |||
FNBP1 Antibody (C-9) Alexa Fluor® 647 | sc-515414 AF647 | 200 µg/ml | $364.00 | |||
FNBP1 Antibody (C-9) Alexa Fluor® 680 | sc-515414 AF680 | 200 µg/ml | $364.00 | |||
FNBP1 Antibody (C-9) Alexa Fluor® 790 | sc-515414 AF790 | 200 µg/ml | $364.00 | |||
FNBP1 (C-9) Neutralizing Peptide | sc-515414 P | 100 µg/0.5 ml | $69.00 |