Molecular structure of Fluspirilene, CAS Number: 1841-19-6
Fluspirilene (CAS 1841-19-6)
Alternate Names:
Redeptin; Imap; R 6218
Application:
Fluspirilene is a dopamine inhibitor and calcium channel protein inhibitor
CAS Number:
1841-19-6
Purity:
≥98%
Molecular Weight:
475.57
Molecular Formula:
C29H31F2N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluspirilene belongs to the class of organic compounds diphenylmethanes. Fluspirilene is a dopamine inhibitor and acts as a potent non-competitive antagonist of L-type calcium channels, it has an IC50 value of 0.03 μM. It is proposed to be a potential antipsychotic.
Fluspirilene (CAS 1841-19-6) References
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- Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors. | Galizzi, JP., et al. 1986. Proc Natl Acad Sci U S A. 83: 7513-7. PMID: 2429309
- Identification of antipsychotic drug fluspirilene as a potential p53-MDM2 inhibitor: a combined computational and experimental study. | Patil, SP., et al. 2015. J Comput Aided Mol Des. 29: 155-63. PMID: 25377899
- In Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug. | Shi, XN., et al. 2015. PLoS One. 10: e0132072. PMID: 26147897
- Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation. | Cortes Cabrera, A., et al. 2016. ACS Chem Biol. 11: 3024-3034. PMID: 27564241
- Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug. | Dong, Y., et al. 2017. Oncotarget. 8: 111728-111741. PMID: 29340087
- Repurposing Screen Identifies Unconventional Drugs With Activity Against Multidrug Resistant Acinetobacter baumannii. | Cheng, YS., et al. 2018. Front Cell Infect Microbiol. 8: 438. PMID: 30662875
- Evaluation of a Library of FDA-Approved Drugs for Their Ability To Potentiate Antibiotics against Multidrug-Resistant Gram-Negative Pathogens. | Hind, CK., et al. 2019. Antimicrob Agents Chemother. 63: PMID: 31160293
- Psychotropic Drugs Show Anticancer Activity by Disrupting Mitochondrial and Lysosomal Function. | Varalda, M., et al. 2020. Front Oncol. 10: 562196. PMID: 33194631
- Exploring potential inhibitor of SARS-CoV2 replicase from FDA approved drugs using insilico drug discovery methods. | Chandra, A., et al. 2022. J Biomol Struct Dyn. 40: 5507-5514. PMID: 33491573
- Unbiased Phenotype-Based Screen Identifies Therapeutic Agents Selective for Metastatic Prostate Cancer. | Chung, I., et al. 2020. Front Oncol. 10: 594141. PMID: 33738243
- Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers. | Fiolek, TJ., et al. 2021. ACS Chem Neurosci. 12: 1438-1448. PMID: 33788542
- Identification of novel Aβ-LilrB2 inhibitors as potential therapeutic agents for Alzheimer's disease. | Lao, K., et al. 2021. Mol Cell Neurosci. 114: 103630. PMID: 34029694
- Recognition of Aβ oligomer by LilrB2 acceptor: a tetracoordinated zipper mechanism. | Ma, X., et al. 2022. J Mol Model. 28: 322. PMID: 36125588
- The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase. | Tabatabaei Dakhili, SA., et al. 2023. Diabetes. 72: 126-134. PMID: 36256885
- The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug. | Janssen, PA., et al. 1970. Arzneimittelforschung. 20: 1689-98. PMID: 4992598
Inhibitor of:
Calcium Channel Protein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluspirilene, 10 mg | sc-252832 | 10 mg | $159.00 | |||
Fluspirilene, 50 mg | sc-252832A | 50 mg | $594.00 |