FLIP_S/L (h2): 293T Lysate: sc-170479

The FLIPS/L (h2): 293T Lysate is derived from the HEK293T cell line, a human embryonic kidney cell line widely utilized for its high transfection efficiency, making it an essential tool in molecular and cellular biology research. This lysate contains FLIPS (FLICE-inhibitory protein, short form) and FLIPL (FLICE-inhibitory protein, long form), which are crucial regulators of apoptosis. These proteins inhibit caspase-8 activation by binding to the death-inducing signaling complex (DISC) and preventing the cleavage of procaspase-8, thereby blocking the apoptotic signal transduction pathway. In research, the FLIPS/L (h2): 293T Lysate is used to investigate the molecular mechanisms governing apoptosis and cell survival. Researchers utilize this lysate to study the interactions between FLIPS/L and components of the DISC, analyze post-translational modifications, and examine the regulatory pathways that control FLIPS/L expression and activity. It is particularly valuable in in vitro assays aimed at understanding how FLIPS/L modulate the balance between cell death and survival, which is critical in processes such as immune response and development. Additionally, this lysate aids in screening for potential modulators of FLIPS/L activity, providing insights into the complex dynamics of apoptotic regulation. By leveraging this lysate, scientists can gain a deeper understanding of the signaling networks involved in apoptosis and the broader implications for cell biology.