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Fipexide hydrochloride (CAS 34161-23-4)

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Alternate Names:
1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine HCl
CAS Number:
34161-23-4
Molecular Weight:
425.31
Molecular Formula:
C20H21ClN2O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fipexide hydrochloride functions as a selective dopamine reuptake inhibitor. It acts by binding to the dopamine transporter and inhibiting the reuptake of dopamine into presynaptic neurons, leading to an increase in extracellular dopamine levels. This mechanism of action results in enhanced dopaminergic neurotransmission in the brain. At the molecular level, fipexide hydrochloride interacts with the dopamine transporter protein, preventing the removal of dopamine from the synaptic cleft and prolonging its action at the postsynaptic receptor. Fipexide Hydrochloride′s mechanism of action is specific to the dopaminergic system, modulating neurotransmission in experimental models.


Fipexide hydrochloride (CAS 34161-23-4) References

  1. Investigating the in vitro metabolism of fipexide: characterization of reactive metabolites using liquid chromatography/mass spectrometry.  |  Sleno, L., et al. 2007. Rapid Commun Mass Spectrom. 21: 2301-11. PMID: 17577876
  2. Determining protein adducts of fipexide: mass spectrometry based assay for confirming the involvement of its reactive metabolite in covalent binding.  |  Sleno, L., et al. 2007. Rapid Commun Mass Spectrom. 21: 4149-57. PMID: 18022964
  3. Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching.  |  Leblanc, A., et al. 2010. Rapid Commun Mass Spectrom. 24: 1241-50. PMID: 20391594
  4. Alternative CHCA-based matrices for the analysis of low molecular weight compounds by UV-MALDI-tandem mass spectrometry.  |  Porta, T., et al. 2011. J Mass Spectrom. 46: 144-52. PMID: 21259393
  5. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke.  |  Beraki, S., et al. 2013. PLoS One. 8: e69233. PMID: 23874920
  6. A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy.  |  Atkin, TA., et al. 2018. Epilepsia. 59: 802-813. PMID: 29574705
  7. Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen Candida auris.  |  de Oliveira, HC., et al. 2019. Front Cell Infect Microbiol. 9: 83. PMID: 31001487
  8. Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis.  |  Vilar, R., et al. 2021. Thromb Haemost. 121: 433-448. PMID: 33302304
  9. Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris.  |  Billamboz, M., et al. 2021. Microorganisms. 9: PMID: 33803604
  10. Establishment of an efficient transformation method of garden stock (Matthiola incana) using a callus formation chemical inducer.  |  Tanahara, Y., et al. 2022. Plant Biotechnol (Tokyo). 39: 273-280. PMID: 36349235

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fipexide hydrochloride, 5 g

sc-235136
5 g
$46.00

What is the solubility of this product in Methanol?

Asked by: hawkeye11
Fipexide hydrochloride (CAS 34161-24-5) produces a clear colorless solution when dissolved in methanol at a concentration of 50 mg/ml.
Answered by: Tech Service 11
Date published: 2016-12-22
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Rated 5 out of 5 by from Durand et alDurand et al. (PubMed ID 1506632) found that fipexide hydrochloride can induce massive liver cell necrosis and fulminant liver failure. -SCBT Publication Review
Date published: 2015-06-07
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Fipexide hydrochloride is rated 5.0 out of 5 by 1.
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