Fibulin-2 Antibody (B-10): sc-271263

Fibulin-2 Antibody (B-10) is a mouse monoclonal IgG1 antibody that detects Fibulin-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fibulin-2 plays a crucial role in the extracellular matrix, where Fibulin-2 interacts with various proteins, including aggrecan, versican, and brevican, which are essential for maintaining the structural integrity and function of connective tissues. This interaction is particularly important in the heart, placenta, and ovarian tissues, where Fibulin-2 is abundantly expressed and localizes to basement membranes and connective tissue compartments. Fibulin-2 presence in these areas suggests involvement in tissue development and repair, as well as in pathological conditions such as diabetic kidney disease and glomerulosclerosis, where Fibulin-2 expression levels can indicate disease progression. The gene encoding human Fibulin-2 is located on chromosome 3p25.1, and understanding Fibulin-2 function and interactions can provide valuable insights into roles in both normal physiology and disease states. Anti-Fibulin-2 antibody (B-10) is an essential tool for researchers investigating the dynamics of extracellular matrix proteins and their implications in various biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Fibulin-2 Antibody (B-10) References:

1. Spatiotemporal changes of fibronectin, tenascin-C, fibulin-1, and fibulin-2 in the skin during the development of chronic contact dermatitis.  |  Kusubata, M., et al. 1999. J Invest Dermatol. 113: 906-12. PMID: 10594729
2. Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stroma.  |  Gu, YC., et al. 2000. Br J Haematol. 109: 305-13. PMID: 10848816
3. Fibulin-2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels.  |  Tsuda, T., et al. 2001. Dev Dyn. 222: 89-100. PMID: 11507771
4. Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering.  |  Lemaire, R., et al. 2004. J Invest Dermatol. 123: 1063-9. PMID: 15610515
5. Loss of fibulin-2 expression is associated with breast cancer progression.  |  Yi, CH., et al. 2007. Am J Pathol. 170: 1535-45. PMID: 17456760
6. Fibulin-2 is a key mediator of the pro-neurogenic effect of TGF-beta1 on adult neural stem cells.  |  Radice, PD., et al. 2015. Mol Cell Neurosci. 67: 75-83. PMID: 26051800
7. Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition.  |  Serra, N., et al. 2015. PLoS One. 10: e0133875. PMID: 26207907
8. Identification of the extracellular matrix protein Fibulin-2 as a regulator of spinal nerve organization.  |  Schaeffer, J., et al. 2018. Dev Biol. 442: 101-114. PMID: 29944871
9. Fibulin 2 Is Hypermethylated and Suppresses Tumor Cell Proliferation through Inhibition of Cell Adhesion and Extracellular Matrix Genes in Non-Small Cell Lung Cancer.  |  Ma, Y., et al. 2021. Int J Mol Sci. 22: PMID: 34769264
10. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences.  |  Utani, A., et al. 1997. J Biol Chem. 272: 2814-20. PMID: 9006922

The preferred Fibulin-2 antibody is Fibulin-2 Antibody (H-5): sc-271843.