Fibulin-2 Antibody (3B9A11): sc-130082

Fibulin-2 Antibody (3B9A11) is a mouse monoclonal IgG1 antibody that detects Fibulin-2 in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Fibulin-2 plays a crucial role in the extracellular matrix, where Fibulin-2 is primarily located in basement membranes and connective tissue compartments, particularly in the heart, placenta, and ovarian tissue. This localization is significant as Fibulin-2 contributes to the structural integrity and function of these tissues, influencing processes such as cell adhesion, migration, and tissue repair. Additionally, Fibulin-2 interacts with various extracellular matrix proteins, including aggrecan, versican, and brevican, which are essential for maintaining the architecture of the extracellular matrix and facilitating cellular communication. The gene encoding human Fibulin-2 is mapped to chromosome 3p25.1, and Fibulin-2 expression is notably altered in pathological conditions, such as diabetic kidneys and glomerulosclerosis, highlighting Fibulin-2′s potential as a biomarker for disease progression. Anti-Fibulin-2 antibody (3B9A11) is an invaluable tool for researchers investigating the roles of extracellular matrix components in health and disease.

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Fibulin-2 Antibody (3B9A11) References:

1. Expression of extracellular matrix proteins fibulin-1 and fibulin-2 by human corneal fibroblasts.  |  Ducros, E., et al. 2007. Curr Eye Res. 32: 481-90. PMID: 17612964
2. Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury.  |  Chapman, SL., et al. 2010. Arterioscler Thromb Vasc Biol. 30: 68-74. PMID: 19893004
3. Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture.  |  Yamauchi, Y., et al. 2010. Acta Histochem Cytochem. 43: 131-8. PMID: 21245979
4. Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction.  |  Tsuda, T., et al. 2012. J Mol Cell Cardiol. 52: 273-82. PMID: 22100229
5. Fibulin 2, a tyrosine O-sulfated protein, is up-regulated following retinal detachment.  |  Kanan, Y., et al. 2014. J Biol Chem. 289: 13419-33. PMID: 24692557
6. Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.  |  Fontanil, T., et al. 2017. Oncotarget. 8: 13716-13729. PMID: 28099917
7. Loss of fibulin-2 expression is involved in the inhibition of breast cancer invasion and forms a new barrier in addition to the basement membrane.  |  Tan, H., et al. 2017. Oncol Lett. 14: 2663-2668. PMID: 28928811
8. Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling.  |  Patel, MR. and Weaver, AM. 2021. Cell Rep. 34: 108829. PMID: 33691102
9. Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases.  |  Sasaki, T., et al. 1996. Eur J Biochem. 240: 427-34. PMID: 8841408
10. Expression of fibulin-2 by fibroblasts and deposition with fibronectin into a fibrillar matrix.  |  Sasaki, T., et al. 1996. J Cell Sci. 109 (Pt 12): 2895-904. PMID: 9013337

The preferred Fibulin-2 antibody is Fibulin-2 Antibody (H-5): sc-271843.