Fibronectin Antibody (TV-1): sc-69682

Fibronectin Antibody (TV-1) is a mouse monoclonal IgG1 antibody that detects Fibronectin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Fibronectin is a crucial extracellular matrix glycoprotein that plays a significant role in cell adhesion, motility, and wound healing, making Fibronectin essential for tissue repair and regeneration. This high molecular weight heterodimeric protein exists on most cell surfaces, extracellular fluids, and plasma, highlighting Fibronectin′s importance in various physiological processes. Fibronectin′s structure, characterized by multiple domains that facilitate interactions with other matrix components and cells, is vital for maintaining tissue integrity and facilitating cellular communication. Alternative splicing and glycosylation of Fibronectin lead to different isoforms, some associated with specific tissues or pathological conditions, such as malignancies. Glycosylated Fibronectin and splice variants have been linked to myofibroblast phenotype formation in Dupuytren′s disease, underscoring Fibronectin′s relevance in both normal physiology and disease states. Anti-Fibronectin antibody (TV-1) serves as an invaluable tool for researchers studying extracellular matrix component dynamics and their implications in health and disease.

The preferred Fibronectin antibody is Fibronectin Antibody (EP5): sc-8422.