Fibronectin Antibody (P5F3): sc-18827

Fibronectin Antibody (P5F3) is a mouse monoclonal IgM kappa light chain antibody that detects Fibronectin in mouse, rat, human, and primate samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Fibronectin is a crucial extracellular matrix glycoprotein that plays a significant role in cell adhesion, motility, and wound healing, making Fibronectin essential for tissue repair and regeneration. This high molecular weight heterodimeric protein is found on most cell surfaces, in extracellular fluids, and in plasma, and Fibronectin′s presence is vital for maintaining the structural integrity of tissues. Fibronectin′s functionality is further enhanced by post-translational modifications, including alternative splicing and glycosylation, which lead to the generation of various isoforms that can exhibit specific tissue distributions and associations with certain diseases, such as malignancies. Notably, glycosylated Fibronectin and splice variants have been linked to the formation of the myofibroblast phenotype in conditions like Dupuytren′s disease, highlighting Fibronectin′s importance in both normal physiological processes and pathological states. Anti-Fibronectin antibody (P5F3) is available in a non-conjugated form, providing researchers with a reliable tool for studying the diverse roles of Fibronectin in various biological contexts.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fibronectin Antibody (P5F3) has 28 citations in a variety of scientific publications.

Primary antibodies like Anti-Fibronectin Antibody (P5F3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fibronectin Antibody (P5F3) Specifications

Alternate Product Name: Fibronectin

Product Clone Name: P5F3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Fibronectin

Epitope Species: human

Product Reactivity/Detection: the adhesive peptide FN Ch/1 within the carboxyl HepII region of Fibronectin

Species Reactivity/Detection: mouse, rat, human, primate

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 28 citations in various scientific publications

Available Conjugates/Forms for Fibronectin Antibody (P5F3): N/A

The preferred Fibronectin antibody is Fibronectin Antibody (EP5): sc-8422.