Fibrinogen α Antibody (1F7): sc-51892

Fibrinogen α Antibody (1F7) is a mouse monoclonal IgG2a antibody that detects Fibrinogen α in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Fibrinogen α is one of the three subunits of the plasma glycoprotein Fibrinogen, which plays a crucial role in the coagulation cascade, particularly in the formation of Fibrin, the primary component of blood clots. Fibrinogen α is synthesized in the liver and is essential for platelet aggregation, which is vital for hemostasis following tissue injury. Upon vascular damage, Fibrinogen α is cleaved by Thrombin, resulting in the formation of Fibrin, which not only serves as a scaffold for clot formation but also regulates cell adhesion and spreading, exhibiting vasoconstrictor and chemotactic properties. The cleavage products of Fibrinogen α act as mitogens for various cell types, highlighting its importance in wound healing and tissue repair. Anti-Fibrinogen α antibody (1F7) is an invaluable tool for researchers studying coagulation processes, vascular biology, and related pathologies, providing insights into the mechanisms underlying hemostasis and thrombosis.

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Fibrinogen α Antibody (1F7) References:

1. Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.  |  Jacquemin, B., et al. 2008. J Am Coll Cardiol. 52: 941-52. PMID: 18772067
2. Fibrinogen alpha chain O-glycopeptides as possible markers of urinary tract infection.  |  Pacchiarotta, T., et al. 2012. J Proteomics. 75: 1067-73. PMID: 22075168
3. Fibrinogen α-chain-derived peptide is upregulated in hippocampus of rats exposed to acute morphine injection and spontaneous alternation testing.  |  Maki, AE., et al. 2014. Pharmacol Res Perspect. 2: e00037. PMID: 24855564
4. Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen α.  |  Zhang, X., et al. 2015. Protein Cell. 6: 757-66. PMID: 26349459
5. A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia.  |  Rao, W., et al. 2017. Dis Markers. 2017: 3104180. PMID: 28203040
6. Isoform 1 of Fibrinogen Alpha Chain Precursor is a Potential Biomarker for Steroid-Induced Osteonecrosis of the Femoral Head.  |  Liu, L., et al. 2020. Proteomics Clin Appl. 14: e1900099. PMID: 32677377
7. Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase/protein kinase B/matrix metallopeptidase 2 pathway†.  |  Li, H., et al. 2020. Biol Reprod. 103: 779-790. PMID: 32697296
8. Interplay of fibrinogen αEC globular domains and factor XIIIa cross-linking dictates the extensibility and strain stiffening of fibrin networks.  |  Martinez-Torres, C., et al. 2024. J Thromb Haemost. 22: 715-726. PMID: 37940047
9. Immune reactivity directed against the carbamylated fibrinogen α chain does not cross-react with citrullinated fibrinogen immunodominant peptides in patients with rheumatoid arthritis.  |  Brevet, P., et al. 2024. RMD Open. 10: PMID: 39389619
10. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain.  |  Benson, MD., et al. 1993. Nat Genet. 3: 252-5. PMID: 8097946

The preferred Fibrinogen α antibody is Fibrinogen α Antibody (C-7): sc-398806.