FGF-8 Antibody (2A10): sc-293479

FGF-8 Antibody (2A10) is a mouse monoclonal IgG2a kappa light chain antibody that detects FGF-8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FGF-8 antibody (2A10) is available as the non-conjugated format. FGF-8 plays a crucial role in embryonic development and tissue repair, acting as a signaling molecule that influences cell proliferation, differentiation, and survival. FGF-8 is particularly important in limb and brain development, regulating growth and patterning of these structures. FGF-8 interacts with specific receptors, including FGFR1, FGFR2, and FGFR3, which are essential for mediating biological effects. Understanding FGF-8 function and interactions is vital for elucidating developmental processes and implications in diseases such as cancer, where aberrant FGF signaling can contribute to tumor growth and metastasis.

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FGF-8 Antibody (2A10) References:

1. Expression of fibroblast growth factor (FGF)-8 isoforms and FGF receptors in human ovarian tumors.  |  Valve, E., et al. 2000. Int J Cancer. 88: 718-25. PMID: 11072239
2. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.  |  Tanaka, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 8928-32. PMID: 1409588
3. FGF-8 is involved in bone metastasis of prostate cancer.  |  Valta, MP., et al. 2008. Int J Cancer. 123: 22-31. PMID: 18386787
4. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
5. Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.  |  Marics, I., et al. 1989. Oncogene. 4: 335-40. PMID: 2649847
6. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family.  |  Delli Bovi, P., et al. 1987. Cell. 50: 729-37. PMID: 2957062
7. Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.  |  Moore, R., et al. 1986. EMBO J. 5: 919-24. PMID: 3013624
8. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.  |  Zhan, X., et al. 1988. Mol Cell Biol. 8: 3487-95. PMID: 3211147
9. Comparison of FGF-8, FGF-10, FGF-Receptor 2, Androgen Receptor, Estrogen Receptor-A and SS in Healthy and Hypospadiac Children.  |  Emaratpardaz, N., et al. 2024. Balkan J Med Genet. 27: 21-29. PMID: 39263642
10. A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth.  |  Mahmood, R., et al. 1995. Curr Biol. 5: 797-806. PMID: 7583127
11. Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis.  |  MacArthur, CA., et al. 1995. J Virol. 69: 2501-7. PMID: 7884899
12. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.  |  Vogel, A., et al. 1996. Development. 122: 1737-50. PMID: 8674413

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGF-8 Antibody (2A10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-FGF-8 Antibody (2A10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGF-8 Antibody (2A10) Specifications

Alternate Product Name: FGF-8

Product Clone Name: 2A10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 65-133

Epitope Target: FGF-8

Epitope Species: human

Product Reactivity/Detection: FGF-8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for FGF-8 Antibody (2A10): N/A