FGF-18 Antibody (C-6): sc-393471

FGF-18 Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects FGF-18 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FGF-18 (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fibroblast Growth Factor 18 (FGF-18) plays a crucial role in the development and maintenance of various tissues, particularly in the skeletal system, where FGF-18 is essential for cartilage formation and repair. FGF-18 is primarily located in the extracellular matrix and is secreted by chondrocytes, which are the cells responsible for cartilage production. FGF-18 localization allows for direct interaction with receptors on neighboring cells, facilitating signaling pathways that promote chondrocyte proliferation and differentiation. Such interactions are particularly important in cartilage repair, helping maintain joint function integrity and supporting healing in conditions like osteoarthritis. FGF-18′s influence on tissue regeneration underscores potential therapeutic applications in regenerative medicine, where enhanced cartilage repair could improve outcomes for patients with degenerative joint diseases.

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FGF-18 Antibody (C-6) References:

1. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.  |  Tanaka, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 8928-32. PMID: 1409588
2. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
3. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
4. Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.  |  Marics, I., et al. 1989. Oncogene. 4: 335-40. PMID: 2649847
5. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family.  |  Delli Bovi, P., et al. 1987. Cell. 50: 729-37. PMID: 2957062
6. Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.  |  Moore, R., et al. 1986. EMBO J. 5: 919-24. PMID: 3013624
7. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.  |  Zhan, X., et al. 1988. Mol Cell Biol. 8: 3487-95. PMID: 3211147
8. Lentivirus-mediated transfer of gene encoding fibroblast growth factor-18 inhibits intervertebral disc degeneration.  |  Lu, S. and Lin, CW. 2021. Exp Ther Med. 22: 856. PMID: 34178129
9. Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway.  |  Tong, G., et al. 2022. Pharmacol Res. 178: 106139. PMID: 35202822
10. Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis.  |  Tsuchiya, Y., et al. 2023. Nat Commun. 14: 6304. PMID: 37813881
11. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.  |  Miyamoto, M., et al. 1993. Mol Cell Biol. 13: 4251-9. PMID: 8321227
12. Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression.  |  Beer, HD., et al. 1997. Oncogene. 15: 2211-8. PMID: 9393979

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGF-18 Antibody (C-6) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-FGF-18 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGF-18 Antibody (C-6) Specifications

Alternate Product Name: FGF-18

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 93-136

Epitope Target: FGF-18

Epitope Species: human

Product Reactivity/Detection: FGF-18

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for FGF-18 Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin