Fer Antibody (5D2C4): sc-81708
- Fer Antibody (5D2C4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 280-474 of Fer of human origin
- recommended for detection of Fer of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fer Antibody (5D2C4). This work is in progress.
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Fer Antibody (5D2C4) is a mouse monoclonal IgG1 antibody that detects Fer in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Fer is a non-receptor protein-tyrosine kinase belonging to the Fes/Fps family, which is characterized by a unique functional SH2 domain and role in mediating signaling pathways associated with receptor tyrosine kinases and cytokine receptors. Fer forms homotrimers in vivo through conserved coiled-coil domains, which is crucial for regulatory functions. The N-terminal coiled-coil domains of Fer can undergo autophosphorylation in trans, allowing for modulation of cellular activities based on different phosphorylation states. This dynamic regulation becomes particularly important during growth factor exposure, which can lead to tyrosine phosphorylation of Fer and subsequent recruitment to receptor tyrosine kinase complexes that include p85. Fer′s functions extend to critical biological processes such as insulin signaling, cell-cell communication, and the progression of human prostatic proliferative diseases, highlighting significance in cellular regulation and potential therapeutic targets. Anti-Fer antibody (5D2C4) serves as an essential tool for researchers investigating these pathways and Fer′s role in various physiological and pathological contexts.
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Fer Antibody (5D2C4) References:
- FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. | Guo, C. and Stark, GR. 2011. Proc Natl Acad Sci U S A. 108: 7968-73. PMID: 21518868
- Fer kinase limits neutrophil chemotaxis toward end target chemoattractants. | Khajah, M., et al. 2013. J Immunol. 190: 2208-16. PMID: 23355730
- FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance. | Ivanova, IA., et al. 2013. Oncogene. 32: 5582-92. PMID: 23873028
- MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. | Chen, ZH., et al. 2017. Gastroenterology. 153: 1120-1132.e15. PMID: 28245430
- Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells. | Mehazri, L., et al. 2021. Int J Mol Sci. 22: PMID: 33806191
- Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness. | Zhang, Y., et al. 2023. J Biol Chem. 299: 104825. PMID: 37196766
- A critique on the suitability of Fer expansion in time-evolution studies in quantum mechanics. | Ganguly, S. and Ramachandran, R. 2023. J Chem Phys. 159: PMID: 37947512
- Ultrasmall Pd Clusters in FER Zeolite Alleviate CO Poisoning for Effective Low-Temperature Carbon Monoxide Oxidation. | Song, I., et al. 2023. J Am Chem Soc. 145: 27493-27499. PMID: 38059304
- Fer governs mTORC1 regulating pathways and sustains viability of pancreatic ductal adenocarcinoma cells. | Schrier, I., et al. 2024. Front Oncol. 14: 1427029. PMID: 39206154
- CRISPR-Cas9 screening identifies the role of FER as a tumor suppressor. | Wang, J., et al. 2025. J Pathol. 265: 158-171. PMID: 39648412
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fer Antibody (5D2C4) | sc-81708 | 200 µg/ml | $322.00 |