Fc ε RIβ Antibody (5-RE9): sc-134340

Fc ε RIβ Antibody (5-RE9) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Fc epsilon RI beta protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Fc epsilon RI beta antibody (5-RE9) is available as a non-conjugated format. Fc epsilon RI beta protein plays a crucial role in the immune response, particularly in mediating allergic reactions. Fc epsilon RI beta protein is a component of the high-affinity IgE receptor, which binds to the Fc region of immunoglobulin E with high affinity, initiating the allergic response upon allergen exposure. This activation leads to the release of various mediators, including histamines, which are responsible for the symptoms associated with allergies. Structurally, Fc epsilon RI beta protein is part of a tetrameric complex that includes a heavily glycosylated alpha chain, a beta chain, and two disulfide-linked gamma chains. The beta chain features four transmembrane regions and long cytoplasmic domains that are essential for intracellular signaling. The cytoplasmic domains of both the beta and gamma subunits contain an immunoreceptor tyrosine activation motif (ITAM), which is critical for signal transduction in mast cells and other hematopoietic cells. Phosphorylation of specific tyrosine residues within this motif is necessary for effective signaling, and variations in the beta subunit, such as the variant at Glu-237, have been linked to increased susceptibility to atopic dermatitis and asthma.

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Fc ε RIβ Antibody (5-RE9) References:

1. Mutational analysis of the high affinity immunoglobulin E receptor beta subunit gene in asthma.  |  Dickson, PW., et al. 1999. Thorax. 54: 409-12. PMID: 10212104
2. The beta subunit of the Fc epsilon RI is associated with the Fc gamma RIII on mast cells.  |  Kurosaki, T., et al. 1992. J Exp Med. 175: 447-51. PMID: 1531062
3. Association between cord blood IgE and genetic polymorphisms of interleukin-4, the beta-subunit of the high-affinity receptor for IgE, lymphotoxin-alpha, and tumor necrosis factor-alpha.  |  Wen, HJ., et al. 2006. Pediatr Allergy Immunol. 17: 489-94. PMID: 17014622
4. Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions.  |  Adra, CN., et al. 1994. Proc Natl Acad Sci U S A. 91: 10178-82. PMID: 7524084
5. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.  |  Shirakawa, T., et al. 1994. Nat Genet. 7: 125-9. PMID: 7920628
6. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.  |  Sandford, AJ., et al. 1993. Lancet. 341: 332-4. PMID: 8094113
7. The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals.  |  Lin, S., et al. 1996. Cell. 85: 985-95. PMID: 8674126
8. Lack of association between atopy and the Ile181Leu variant of the beta-subunit of the high-affinity immunoglobulin E receptor.  |  Kofler, H., et al. 1996. Int Arch Allergy Immunol. 111: 44-7. PMID: 8753843
9. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.  |  Hill, MR. and Cookson, WO. 1996. Hum Mol Genet. 5: 959-62. PMID: 8817330
10. IL-3, IL-5, granulocyte-macrophage colony-stimulating factor receptor alpha-subunit, and common beta-subunit expression by peripheral leukocytes and blood dendritic cells.  |  Yamada, T., et al. 1998. J Allergy Clin Immunol. 101: 677-82. PMID: 9600506

The preferred Fc ε RIβ antibody is Fc ε RIβ Antibody (F-1): sc-393789.