FBXO28 Antibody (C-8): sc-376851
- FBXO28 Antibody (C-8) is a mouse monoclonal IgG1 κ FBXO28 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 69-368 mapping at the C-terminus of FBXO28 of human origin
- FBXO28 Antibody (C-8) is recommended for detection of FBXO28 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-FBXO28 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for FBXO28 Antibody (C-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with FBXO28 Antibody (C-8) (see ordering information below).
FBXO28 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects FBXO28 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FBXO28 (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FBXO28, also known as F-box protein 28, is a 368 amino acid protein characterized by the presence of one F-box domain, which is essential for its role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex. This complex is crucial for substrate recognition and recruitment for ubiquitination, a process that regulates protein degradation and maintains cellular homeostasis. FBXO28′s ability to target specific substrates, such as cyclins and IκB-α, for proteasomal degradation underscores its importance in controlling various cellular processes, including the cell cycle and immune responses. The gene encoding FBXO28 is located on human chromosome 1, a region encompassing nearly 8% of the human genome and including numerous genes associated with various diseases, such as familial adenomatous polyposis and Parkinson′s disease. Anti-FBXO28 antibody (C-8)′s versatility in multiple applications makes this reagent an invaluable tool for researchers studying the intricate roles of F-box proteins in cellular regulation and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FBXO28 Antibody (C-8) References:
- Identification of a family of human F-box proteins. | Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
- A family of mammalian F-box proteins. | Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
- cDNA cloning and expression analysis of new members of the mammalian F-box protein family. | Ilyin, GP., et al. 2000. Genomics. 67: 40-7. PMID: 10945468
- Exclusion of an extracolonic disease modifier locus on chromosome 1p33-36 in a large Swiss familial adenomatous polyposis kindred. | Plasilova, M., et al. 2004. Eur J Hum Genet. 12: 365-71. PMID: 14735163
- Systematic analysis and nomenclature of mammalian F-box proteins. | Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
- Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. | Oliveira, SA., et al. 2005. Am J Hum Genet. 77: 252-64. PMID: 15986317
- Analysis of the vitreous membrane in a case of type 1 Stickler syndrome. | Yokoi, T., et al. 2009. Graefes Arch Clin Exp Ophthalmol. 247: 715-8. PMID: 19089441
- Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa. | Eudy, JD., et al. 1998. Science. 280: 1753-7. PMID: 9624053
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FBXO28 Antibody (C-8) | sc-376851 | 200 µg/ml | $316.00 | |||
FBXO28 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-526056 | 200 µg Ab; 10 µg BP | $354.00 | |||
FBXO28 Antibody (C-8) AC | sc-376851 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FBXO28 Antibody (C-8) HRP | sc-376851 HRP | 200 µg/ml | $316.00 | |||
FBXO28 Antibody (C-8) FITC | sc-376851 FITC | 200 µg/ml | $330.00 | |||
FBXO28 Antibody (C-8) PE | sc-376851 PE | 200 µg/ml | $343.00 | |||
FBXO28 Antibody (C-8) Alexa Fluor® 488 | sc-376851 AF488 | 200 µg/ml | $357.00 | |||
FBXO28 Antibody (C-8) Alexa Fluor® 546 | sc-376851 AF546 | 200 µg/ml | $357.00 | |||
FBXO28 Antibody (C-8) Alexa Fluor® 594 | sc-376851 AF594 | 200 µg/ml | $357.00 | |||
FBXO28 Antibody (C-8) Alexa Fluor® 647 | sc-376851 AF647 | 200 µg/ml | $357.00 | |||
FBXO28 Antibody (C-8) Alexa Fluor® 680 | sc-376851 AF680 | 200 µg/ml | $357.00 | |||
FBXO28 Antibody (C-8) Alexa Fluor® 790 | sc-376851 AF790 | 200 µg/ml | $357.00 |