FBXO25 Antibody (F9-3): sc-100735
- FBXO25 Antibody (F9-3) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant FBXO25 of human origin
- recommended for detection of FBXO25 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FBXO25 Antibody (F9-3). This work is in progress.
FBXO25 Antibody (F9-3) is a mouse monoclonal IgG2a antibody that detects FBXO25 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). FBXO25, also known as F-box only protein 25, is a 367 amino acid protein characterized by a C-terminal F-box domain, which is essential for its role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex. This complex is crucial for the ubiquitination process, allowing for the targeted degradation of various proteins that regulate key cellular functions, including the cell cycle and immune responses. Notably, FBXO25 is predominantly localized in the nucleus, where FBXO25 interacts directly with Skp1 p19 and CUL-1, facilitating the recognition and recruitment of substrates for ubiquitination. Proper functioning of FBXO25 is vital, as disruptions in FBXO25 can lead to severe consequences, such as X-linked mental retardation, highlighting its importance in neurodevelopmental processes. Anti-FBXO25 antibody (F9-3) is an invaluable tool for researchers investigating the intricate roles of ubiquitin ligases in cellular regulation and disease mechanisms.
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FBXO25 Antibody (F9-3) References:
- FBXO25, an F-box protein homologue of atrogin-1, is not induced in atrophying muscle. | Maragno, AL., et al. 2006. Biochim Biophys Acta. 1760: 966-72. PMID: 16714087
- FBXO25-associated nuclear domains: a novel subnuclear structure. | Manfiolli, AO., et al. 2008. Mol Biol Cell. 19: 1848-61. PMID: 18287534
- Identification of FBXO25-interacting proteins using an integrated proteomics approach. | Teixeira, FR., et al. 2010. Proteomics. 10: 2746-57. PMID: 20473970
- A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors. | Jang, JW., et al. 2011. Biochem Biophys Res Commun. 410: 183-8. PMID: 21596019
- The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. | Teixeira, FR., et al. 2013. J Biol Chem. 288: 28152-62. PMID: 23940030
- Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. | Jeong, HS., et al. 2015. Biochim Biophys Acta. 1849: 709-21. PMID: 25725482
- FBXO25 promotes cell proliferation, invasion, and migration of NSCLC. | Jiang, GY., et al. 2016. Tumour Biol. 37: 14311-14319. PMID: 27596142
- FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation. | Teixeira, FR., et al. 2017. Arch Biochem Biophys. 621: 38-45. PMID: 28389297
- From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes. | Harich, B., et al. 2020. J Child Psychol Psychiatry. 61: 545-555. PMID: 31849056
- FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1. | Kuzmanov, A., et al. 2020. J Invest Dermatol. 140: 2496-2504. PMID: 32335130
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FBXO25 Antibody (F9-3) | sc-100735 | 100 µg/ml | $339.00 |