FATE1 Antibody (B5-9): sc-101220

FATE1 Antibody (B5-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects FATE1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FATE1 antibody (B5-9) is available as the non-conjugated format. FATE1, also known as fetal and adult testis expressed 1, CT43 (cancer/testis antigen 43), or BJ-HCC-2, is a cancer/testis antigen primarily expressed in testis and various tumor tissues, particularly in hepatocarcinoma cells. FATE1 plays a crucial role in early testicular differentiation, as FATE1 is exclusively expressed in the testis of 6-11 week old fetuses, coinciding with the period of gonadal sex differentiation. Notably, at around 7 weeks of gestation, FATE1 is coexpressed with the SRY gene, which is essential for male sex determination, indicating FATE1′s potential involvement in the development of male reproductive organs. In adults, while FATE1 is predominantly found in the testis, FATE1 is also present in other tissues such as the heart, kidney, brain, lung, and adrenal gland, suggesting a broader biological significance. Furthermore, FATE1 expression is regulated by key proteins involved in tumorigenesis, including Steroidogenic Factor 1 and Wilms′ tumor protein, highlighting FATE1′s potential role in cancer development. Importantly, mutations in the gene encoding FATE1 have been implicated in male infertility, making FATE1 a significant target for further research in reproductive health and oncology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FATE1 Antibody (B5-9) References:

1. Human FATE is a novel X-linked gene expressed in fetal and adult testis.  |  Olesen, C., et al. 2001. Mol Cell Endocrinol. 184: 25-32. PMID: 11694338
2. Mutational analysis of the human FATE gene in 144 infertile men.  |  Olesen, C., et al. 2003. Hum Genet. 113: 195-201. PMID: 12811541
3. Identification of two novel CT antigens and their capacity to elicit antibody response in hepatocellular carcinoma patients.  |  Dong, XY., et al. 2003. Br J Cancer. 89: 291-7. PMID: 12865919
4. Purification and refolding of a novel cancer/testis antigen BJ-HCC-2 expressed in the inclusion bodies of Escherichia coli.  |  Yang, XA., et al. 2004. Protein Expr Purif. 33: 332-8. PMID: 14711522
5. Immunohistochemical analysis of the expression of FATE/BJ-HCC-2 antigen in normal and malignant tissues.  |  Yang, XA., et al. 2005. Lab Invest. 85: 205-13. PMID: 15580283
6. Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer.  |  Doghman, M., et al. 2007. Mol Endocrinol. 21: 2968-87. PMID: 17761949

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FATE1 Antibody (B5-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-FATE1 Antibody (B5-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FATE1 Antibody (B5-9) Specifications

Alternate Product Name: FATE1

Product Clone Name: B5-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-101

Epitope Target: FATE1

Epitope Species: human

Product Reactivity/Detection: FATE1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FATE1 Antibody (B5-9): N/A