FANK1 Antibody (F-5): sc-398026
- FANK1 Antibody (F-5) is a mouse monoclonal IgG2a κ FANK1 antibody provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of FANK1 of human origin
- FANK1 Antibody (F-5) is recommended for detection of FANK1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-FANK1 Antibody (F-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FANK1 Antibody (F-5) for WB and IHC(P) applications. These reagents are now offered in bundles with FANK1 Antibody (F-5) (see ordering information below).
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SEE ALSO...
FANK1 Antibody (F-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects FANK1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FANK1 (F-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FANK1, also known as fibronectin type III and ankyrin repeat domains 1 or HSD13, is a 345 amino acid protein predominantly localized in the nucleus and cytoplasm of testis-specific cells, particularly in pachytene spermatocytes and round spermatids. The presence of six ankyrin repeats and a single fibronectin type-III domain in FANK1′s structure is crucial, as these motifs mediate protein-protein interactions, which are essential for cellular signaling and regulatory processes. FANK1 functions as a transcription factor, playing a significant role in regulating gene expression during spermatogenesis, a critical process for male fertility. The gene encoding FANK1 is located on human chromosome 10, a region harboring over 800 genes and associated with various genetic conditions, including Cowden syndrome, which is linked to mutations in the tumor suppressor gene PTEN. FANK1′s ability to undergo alternative splicing to produce multiple isoforms further highlights functional versatility and importance in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FANK1 Antibody (F-5) References:
- Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis. | Zheng, Z., et al. 2007. Gene Expr Patterns. 7: 777-83. PMID: 17604233
- Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation. | Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
- Genes to diseases (G2D) computational method to identify asthma candidate genes. | Tremblay, K., et al. 2008. PLoS One. 3: e2907. PMID: 18682798
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. | Trynka, G., et al. 2009. Gut. 58: 1078-83. PMID: 19240061
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANK1 Antibody (F-5) | sc-398026 | 200 µg/ml | $316.00 | |||
FANK1 Antibody (F-5): m-IgG Fc BP-HRP Bundle | sc-530669 | 200 µg Ab; 10 µg BP | $354.00 | |||
FANK1 Antibody (F-5): m-IgGκ BP-HRP Bundle | sc-524189 | 200 µg Ab, 40 µg BP | $354.00 | |||
FANK1 Antibody (F-5): m-IgG2a BP-HRP Bundle | sc-547551 | 200 µg Ab; 10 µg BP | $354.00 | |||
FANK1 Antibody (F-5) AC | sc-398026 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FANK1 Antibody (F-5) HRP | sc-398026 HRP | 200 µg/ml | $316.00 | |||
FANK1 Antibody (F-5) FITC | sc-398026 FITC | 200 µg/ml | $330.00 | |||
FANK1 Antibody (F-5) PE | sc-398026 PE | 200 µg/ml | $343.00 | |||
FANK1 Antibody (F-5) Alexa Fluor® 488 | sc-398026 AF488 | 200 µg/ml | $357.00 | |||
FANK1 Antibody (F-5) Alexa Fluor® 546 | sc-398026 AF546 | 200 µg/ml | $357.00 | |||
FANK1 Antibody (F-5) Alexa Fluor® 594 | sc-398026 AF594 | 200 µg/ml | $357.00 | |||
FANK1 Antibody (F-5) Alexa Fluor® 647 | sc-398026 AF647 | 200 µg/ml | $357.00 | |||
FANK1 Antibody (F-5) Alexa Fluor® 680 | sc-398026 AF680 | 200 µg/ml | $357.00 | |||
FANK1 Antibody (F-5) Alexa Fluor® 790 | sc-398026 AF790 | 200 µg/ml | $357.00 |