FANCE Antibody (B-1): sc-398558
- FANCE Antibody (B-1) is a mouse monoclonal IgG1 κ FANCE antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 237-536 mapping at the C-terminus of FANCE of human origin
- FANCE Antibody (B-1) is recommended for detection of FANCE of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-FANCE Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for FANCE Antibody (B-1) for WB applications. These reagents are now offered in bundles with FANCE Antibody (B-1) (see ordering information below).
FANCE Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects FANCE protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FANCE Antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FANCE protein plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for maintaining genomic stability and repairing DNA cross-links. Mutations in FANCE gene can lead to Fanconi anemia, an autosomal recessive disorder characterized by bone marrow failure, developmental abnormalities, and increased cancer susceptibility. FANCE protein, encoded by the gene located on chromosome 6p22-p21, consists of 536 amino acids and features two potential nuclear localization signals, indicating an important role in nuclear processes. Additionally, FANCE protein interacts with other FA proteins, including FANCD2 and BRCA1, to facilitate FANCD2 monoubiquitination, a critical step in DNA repair. Understanding FANCE protein function and interactions is vital for elucidating mechanisms underlying Fanconi anemia and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FANCE Antibody (B-1) References:
- Isolation of a cDNA representing the Fanconi anemia complementation group E gene. | de Winter, JP., et al. 2000. Am J Hum Genet. 67: 1306-8. PMID: 11001585
- The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. | de Winter, JP., et al. 2000. Hum Mol Genet. 9: 2665-74. PMID: 11063725
- A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA. | Yagasaki, H., et al. 2001. Blood. 98: 3650-7. PMID: 11739169
- Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells. | Siddique, MA., et al. 2001. Exp Hematol. 29: 1448-55. PMID: 11750104
- The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange. | Wilson, JB., et al. 2001. Carcinogenesis. 22: 1939-46. PMID: 11751423
- Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase. | Otsuki, T., et al. 2002. Biochem Biophys Res Commun. 291: 628-34. PMID: 11855836
- Molecular pathogenesis of fanconi anemia. | Taniguchi, T. and Dandrea, AD. 2002. Int J Hematol. 75: 123-8. PMID: 11939257
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCE Antibody (B-1) | sc-398558 | 200 µg/ml | $322.00 | |||
FANCE Antibody (B-1): m-IgG Fc BP-HRP Bundle | sc-527787 | 200 µg Ab; 10 µg BP | $361.00 | |||
FANCE Antibody (B-1): m-IgG1 BP-HRP Bundle | sc-533160 | 200 µg Ab; 20 µg BP | $361.00 | |||
FANCE Antibody (B-1) AC | sc-398558 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FANCE Antibody (B-1) HRP | sc-398558 HRP | 200 µg/ml | $322.00 | |||
FANCE Antibody (B-1) FITC | sc-398558 FITC | 200 µg/ml | $336.00 | |||
FANCE Antibody (B-1) PE | sc-398558 PE | 200 µg/ml | $349.00 | |||
FANCE Antibody (B-1) Alexa Fluor® 488 | sc-398558 AF488 | 200 µg/ml | $364.00 | |||
FANCE Antibody (B-1) Alexa Fluor® 546 | sc-398558 AF546 | 200 µg/ml | $364.00 | |||
FANCE Antibody (B-1) Alexa Fluor® 594 | sc-398558 AF594 | 200 µg/ml | $364.00 | |||
FANCE Antibody (B-1) Alexa Fluor® 647 | sc-398558 AF647 | 200 µg/ml | $364.00 | |||
FANCE Antibody (B-1) Alexa Fluor® 680 | sc-398558 AF680 | 200 µg/ml | $364.00 | |||
FANCE Antibody (B-1) Alexa Fluor® 790 | sc-398558 AF790 | 200 µg/ml | $364.00 |