Famprofazone (CAS 22881-35-2)
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Famprofazone is a non-steroidal anti-inflammatory chemical that functions as an inhibitor of cyclooxygenase, COX-1 and COX-2 enzymes. It exerts its mode of action by inhibiting the production of prostaglandins, which are lipid compounds involved in the response to injury and inflammation. By blocking the activity of the cyclooxygenase enzymes, famprofazone reduces the synthesis of prostaglandins from arachidonic acid, thereby diminishing the inflammatory response. Famprofazone′s mechanism of action involves binding to the active site of the cyclooxygenase enzymes, preventing the conversion of arachidonic acid to prostaglandins. This inhibition of prostaglandin synthesis results in the reduction of pain, fever, and inflammation. Famprofazone′s mode of action at the molecular level involves interfering with the enzymatic activity of cyclooxygenase, ultimately leading to the suppression of prostaglandin production.
Famprofazone (CAS 22881-35-2) References
- Metabolic profile of amphetamine and methamphetamine following administration of the drug famprofazone. | Greenhill, B., et al. 2003. J Anal Toxicol. 27: 479-84. PMID: 14607003
- Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man. | Oh, ES., et al. 1992. Xenobiotica. 22: 377-84. PMID: 1496827
- Famprofazone as the source of methamphetamine and amphetamine in urine specimen collected during sport competition. | Tseng, YL., et al. 2007. J Forensic Sci. 52: 479-86. PMID: 17316255
- Famprofazone use can be misinterpreted as methamphetamine abuse. | Chan, KH., et al. 2010. J Anal Toxicol. 34: 347-53. PMID: 20663288
- Metabolic Precursors to Amphetamine and Methamphetamine. | Cody, JD. 1993. Forensic Sci Rev. 5: 109-27. PMID: 26270078
- Postmortem analysis of famprofazone and its metabolites, methamphetamine and amphetamine, in porcine bone marrow. | de Souza Santos, E., et al. 2019. Talanta. 191: 545-552. PMID: 30262097
- Determination of famprofazone, amphetamine and methamphetamine in liver samples using enzymatic cell dispersion and SPE-LC-ESI-MS. | da Silva, CML., et al. 2022. J Pharm Biomed Anal. 217: 114821. PMID: 35598557
- Detection and identification of famprofazone and its metabolite in human urine. | Shin, HS., et al. 1994. J Chromatogr B Biomed Appl. 661: 255-61. PMID: 7894665
- Urinary methamphetamine concentration following famprofazone administration. | Yoo, Y., et al. 1994. J Anal Toxicol. 18: 265-8. PMID: 7990444
- Enantiomeric composition of amphetamine and methamphetamine derived from the precursor compound famprofazone. | Cody, JT. 1996. Forensic Sci Int. 80: 189-99. PMID: 8682419
- Stereoselective metabolism of famprofazone in humans: N-dealkylation and beta- and p-hydroxylation. | Shin, HS. 1997. Chirality. 9: 52-8. PMID: 9094203
- Stereoselective metabolic study of famprofazone. | Neugebauer, M., et al. 1997. Biomed Chromatogr. 11: 356-61. PMID: 9413615
- Identification of famprofazone ingestion. | Musshoff, F. and Kraemer, T. 1998. Int J Legal Med. 111: 305-8. PMID: 9826089
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Famprofazone, 10 g | sc-235122 | 10 g | $80.00 |