FAM84A Antibody (BA-9): sc-101207

FAM84A Antibody (BA-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects FAM84A protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-FAM84A antibody (BA-9) is available as the non-conjugated format. FAM84A, also known as family with sequence similarity 84, member A or neurologic sensory protein 1, is a 292 amino acid protein that plays a crucial role in cell morphology and motility, particularly in cancer progression. FAM84A protein is predominantly expressed in the testis and exhibits 44% amino acid identity with its closely related counterpart, FAM84B. FAM84A protein is localized to a subcellular membrane region characterized by a lack of contact between neighboring cells, which is significant for regulating cell shape and movement. FAM84A protein undergoes alternative splicing, resulting in two isoforms, with Isoform 2 being particularly important due to phosphorylation on various serine residues. This post-translational modification is associated with changes in cellular morphology, further emphasizing FAM84A′s role in dynamic cellular processes. FAM84A protein is upregulated in several types of cancer, including colorectal, lung, pancreatic, cholangiocarcinoma, and bladder cancers, suggesting that enhanced cell motility may facilitate cancer cell invasion and metastasis.

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FAM84A Antibody (BA-9) References:

1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.  |  Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
2. A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells.  |  Kobayashi, T., et al. 2006. Int J Oncol. 29: 341-7. PMID: 16820875
3. Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells.  |  Gouyer, V., et al. 2008. Oncogene. 27: 4024-33. PMID: 18317448
4. Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.  |  Pebernard, S., et al. 2008. Mol Biol Cell. 19: 4099-109. PMID: 18667531
5. Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.  |  Kamino, H., et al. 2011. Int J Oncol. 38: 1511-20. PMID: 21424122
6. Identification of a novel autoantigen in inflammatory bowel disease by protein microarray.  |  Vermeulen, N., et al. 2011. Inflamm Bowel Dis. 17: 1291-300. PMID: 21560193
7. Genome-wide linkage and positional association study of blood pressure response to dietary sodium intervention: the GenSalt Study.  |  Mei, H., et al. 2012. Am J Epidemiol. 176 Suppl 7: S81-90. PMID: 22865701
8. Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons.  |  Pérez-Palma, E., et al. 2016. Neural Plast. 2016: 4672841. PMID: 28116168
9. The direct miR-874-3p-target FAM84A promotes tumor development in papillary thyroid cancer.  |  Ding, Y., et al. 2021. Mol Oncol. 15: 1597-1614. PMID: 33751775
10. DNA methylation mediates the association between breastfeeding and early-life growth trajectories.  |  Briollais, L., et al. 2021. Clin Epigenetics. 13: 231. PMID: 34937578
11. Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes.  |  Zhou, Y., et al. 2022. J Dent Res. 101: 1526-1536. PMID: 35771046
12. Epigenome-wide association study identifies novel genes associated with ischemic stroke.  |  Peng, H., et al. 2023. Clin Epigenetics. 15: 106. PMID: 37370144

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FAM84A Antibody (BA-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FAM84A Antibody (BA-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FAM84A Antibody (BA-9) Specifications

Alternate Product Name: FAM84A

Product Clone Name: BA-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-293

Epitope Target: FAM84A

Epitope Species: human

Product Reactivity/Detection: FAM84A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FAM84A Antibody (BA-9): N/A