FAM70B Antibody (E-4): sc-514100

FAM70B Antibody (E-4) is a mouse monoclonal IgM antibody that detects FAM70B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FAM70B antibody (E-4) is available as the non-conjugated form. FAM70B, or family with sequence similarity 70, member B, is a 326 amino acid membrane protein that plays a significant role in cellular processes, particularly in the regulation of cell signaling pathways. FAM70B is primarily located in the endoplasmic reticulum and is involved in the maintenance of cellular homeostasis and the modulation of stress responses. Proper functioning of FAM70B is crucial, as dysregulation has been linked to various diseases, including cancer. The gene encoding FAM70B is situated on human chromosome 13, a region that harbors several key tumor suppressor genes, including BRCA2 and RB1, which are vital for preventing malignant growth. FAM70B presence in the endoplasmic reticulum underscores its importance in protein folding and quality control, which are essential for maintaining cellular integrity and function. FAM70B (E-4) antibody is an invaluable tool for researchers studying the role of FAM70B in health and disease, providing insights into its potential as a biomarker or therapeutic target.

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FAM70B Antibody (E-4) References:

1. The DNA sequence and analysis of human chromosome 13.  |  Dunham, A., et al. 2004. Nature. 428: 522-8. PMID: 15057823
2. A new gene for Tourette's syndrome: a window into causal mechanisms?  |  Grados, MA. and Walkup, JT. 2006. Trends Genet. 22: 291-3. PMID: 16678301
3. RB and cell cycle progression.  |  Giacinti, C. and Giordano, A. 2006. Oncogene. 25: 5220-7. PMID: 16936740
4. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome.  |  Deng, H., et al. 2006. Acta Neurol Scand. 114: 400-2. PMID: 17083340
5. Non-disjunction of chromosome 13.  |  Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
6. Variable expressivity in Patau syndrome is not all related to trisomy 13 mosaicism.  |  Hsu, HF. and Hou, JW. 2007. Am J Med Genet A. 143A: 1739-48. PMID: 17603803
7. The origin of trisomy 13.  |  Hall, HE., et al. 2007. Am J Med Genet A. 143A: 2242-8. PMID: 17853475
8. Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.  |  Hassler, M., et al. 2007. Mol Cell. 28: 371-85. PMID: 17996702
9. BRCA2: a universal recombinase regulator.  |  Thorslund, T. and West, SC. 2007. Oncogene. 26: 7720-30. PMID: 18066084

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FAM70B Antibody (E-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FAM70B Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FAM70B Antibody (E-4) Specifications

Alternate Product Name: FAM70B

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 163-182

Epitope Target: FAM70B

Epitope Species: human

Product Reactivity/Detection: FAM70B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FAM70B Antibody (E-4): P: Blocking Peptide