FAM213A Antibody (H-7): sc-390692

FAM213A Antibody (H-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects FAM213A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-FAM213A antibody (H-7) is available as the non-conjugated form. FAM213A, also known as PAMM (peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) or C10orf58, is a 229 amino acid cytoplasmic protein that belongs to the peroxiredoxin-like FAM213 family and FAM213A subfamily. FAM213A plays a crucial role in redox regulation within cells, acting as an antioxidant that helps mitigate oxidative stress, which is vital for maintaining cellular health and function. FAM213A is induced by colony-stimulating factor 1 (CSF1) in peripheral blood mononuclear cells (PBMCs), highlighting FAM213A′s importance in immune responses and inflammation. The gene encoding FAM213A maps to human chromosome 10, which spans nearly 135 million base pairs and constitutes approximately 4.5% of total DNA in cells, encoding nearly 1,200 genes. FAM213A exists in two alternatively spliced isoforms, further emphasizing FAM213A′s complexity and regulatory potential in various biological processes.

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FAM213A Antibody (H-7) References:

1. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.  |  Yu, Y., et al. 2001. Genome Res. 11: 1392-403. PMID: 11483580
2. Molecular cell biology of Charcot-Marie-Tooth disease.  |  Berger, P., et al. 2002. Neurogenetics. 4: 1-15. PMID: 12030326
3. Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21.  |  Troelstra, C., et al. 1992. Genomics. 12: 745-9. PMID: 1349298
4. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
5. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
6. PTEN: a new guardian of the genome.  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
7. Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.  |  Laugel, V., et al. 2010. Hum Mutat. 31: 113-26. PMID: 19894250
8. PAMM: a redox regulatory protein that modulates osteoclast differentiation.  |  Xu, Y., et al. 2010. Antioxid Redox Signal. 13: 27-37. PMID: 19951071
9. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.  |  Jabs, EW., et al. 1994. Nat Genet. 8: 275-9. PMID: 7874170

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FAM213A Antibody (H-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FAM213A Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FAM213A Antibody (H-7) Specifications

Alternate Product Name: FAM213A

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 152-188

Epitope Target: FAM213A

Epitope Species: human

Product Reactivity/Detection: FAM213A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FAM213A Antibody (H-7): P: Blocking Peptide