FAM213A Inhibitors
Chemical inhibitors of FAM213A can exert their inhibitory effects through various mechanisms, primarily by targeting the cellular pathways that FAM213A is involved in, such as the oxidative stress response. Resveratrol, for example, antagonizes NF-kappaB signaling, a pathway in which FAM213A participates. By blocking NF-kappaB, resveratrol indirectly reduces the functional activity of FAM213A. Similarly, curcumin decreases the activity of transcription factors like NF-kappaB and AP-1, leading to a reduced oxidative stress response and thus diminishing FAM213A activity. Sulforaphane activates Nrf2, which indirectly inhibits FAM213A by potentially downregulating other oxidative pathways FAM213A is involved in. Quercetin interferes with the PI3K/Akt pathway, decreasing FAM213A activity by reducing the cellular oxidative stress response. EGCG, like curcumin and resveratrol, inhibits the activation of NF-kappaB and AP-1, reducing the functional activity of FAM213A.
The antioxidants Butylated hydroxyanisole (BHA) and Butylated hydroxytoluene (BHT) lower the functional demand on FAM213A by mitigating oxidative stress. N-Acetylcysteine (NAC) serves as a precursor to glutathione, an antioxidant that reduces oxidative stress, thereby decreasing the need for FAM213A's oxidative stress response. Trolox, being a vitamin E analogue, provides antioxidative effects that reduce the need for FAM213A's activity within oxidative stress response pathways. Finally, Disulfiram's alteration of the cellular redox state and its interference with alcohol metabolism can impact oxidative stress pathways, which in turn inhibits the functional activity of FAM213A. Each of these chemicals interacts with the oxidative stress-related pathways or cellular processes that FAM213A is involved in, leading to a functional inhibition of the protein.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can inhibit the FAM213A protein by antagonizing the activation of NF-kappaB signaling. FAM213A is known to participate in oxidative stress responses, and NF-kappaB plays a pivotal role in this pathway. By blocking NF-kappaB, resveratrol indirectly inhibits the oxidative stress response, thereby decreasing the functional activity of FAM213A. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can indirectly inhibit FAM213A by reducing the activity of transcription factors such as NF-kappaB and AP-1, both of which are involved in the oxidative stress response where FAM213A functions. By diminishing the cellular response to oxidative stress, curcumin can functionally inhibit FAM213A activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can functionally inhibit FAM213A by activating Nrf2, a transcription factor that regulates antioxidant response elements (AREs). While Nrf2 activation generally promotes antioxidant responses, it can also lead to a compensatory downregulation of other oxidative stress pathways that involve FAM213A, indirectly inhibiting its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can inhibit FAM213A by modulating the PI3K/Akt pathway, which is associated with oxidative stress responses. By interfering with this signaling pathway, quercetin can decrease the functional activity of FAM213A that is involved in managing oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit FAM213A indirectly by inhibiting the activation of NF-kappaB and AP-1, both of which are involved in oxidative stress response pathways. As FAM213A is implicated in these pathways, EGCG's action leads to the functional inhibition of FAM213A by reducing the cellular oxidative stress response. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $30.00 $98.00 | 1 | |
BHA can functionally inhibit FAM213A by acting as an antioxidant, thereby reducing the need for FAM213A's activity within the oxidative stress response. BHA's antioxidative properties can lead to a reduced functional load on FAM213A. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC can inhibit FAM213A by acting as a precursor to glutathione, an antioxidant that reduces oxidative stress. The presence of NAC leads to increased glutathione levels, which can decrease the functional necessity of FAM213A in responding to oxidative stress. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $38.00 $67.00 $235.00 $678.00 $1712.00 | 39 | |
Trolox, a vitamin E analogue, can inhibit FAM213A by acting as an antioxidant, which reduces oxidative stress and thus the need for FAM213A's activity within the oxidative stress response pathways. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit FAM213A indirectly by modifying the cellular redox state and interfering with the metabolism of alcohol, which can impact oxidative stress pathways and thus inhibit the functional activity of FAM213A. | ||||||