Factor XII Antibody (C-8): sc-376770
- Factor XII Antibody (C-8) is a mouse monoclonal IgG1 κ Factor XII antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 76-130 mapping near the N-terminus of Factor XII of human origin
- Factor XII Antibody (C-8) is recommended for detection of Factor XII of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Factor XII Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Factor XII Antibody (C-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with Factor XII Antibody (C-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
Factor XII Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Factor XII protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Factor XII (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Factor XII, also known as Hageman factor, plays a crucial role in initiating the intrinsic pathway of blood coagulation, vital for hemostasis following vascular injury. Upon activation, Factor XII undergoes a conformational change that allows interaction with negatively charged surfaces, leading to Factor XI activation and subsequently triggering a cascade of proteolytic events that culminate in fibrin clot formation. This process is essential for preventing excessive bleeding and ensuring proper wound healing. Additionally, Factor XII has been implicated in various pathological conditions, including thrombosis and inflammation, making Factor XII a significant target for therapeutic interventions. Factor XII (C-8) monoclonal antibody′s versatility in multiple applications allows researchers to explore Factor XII′s role in both normal physiology and disease states, providing valuable insights into coagulation mechanisms and potential treatment strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor XII Antibody (C-8) References:
- Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. | Chambers, RC., et al. 2000. J Biol Chem. 275: 35584-91. PMID: 10952976
- The coagulation cascade: initiation, maintenance, and regulation. | Davie, EW., et al. 1991. Biochemistry. 30: 10363-70. PMID: 1931959
- Basic mechanisms in blood coagulation. | Davie, EW. and Fujikawa, K. 1975. Annu Rev Biochem. 44: 799-829. PMID: 237463
- Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation. | O'Hara, PJ., et al. 1987. Proc Natl Acad Sci U S A. 84: 5158-62. PMID: 3037537
- Characterization of a cDNA coding for human factor VII. | Hagen, FS., et al. 1986. Proc Natl Acad Sci U S A. 83: 2412-6. PMID: 3486420
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor XII Antibody (C-8) | sc-376770 | 200 µg/ml | $322.00 | |||
Factor XII Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-526049 | 200 µg Ab; 10 µg BP | $361.00 | |||
Factor XII Antibody (C-8) AC | sc-376770 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Factor XII Antibody (C-8) HRP | sc-376770 HRP | 200 µg/ml | $322.00 | |||
Factor XII Antibody (C-8) FITC | sc-376770 FITC | 200 µg/ml | $336.00 | |||
Factor XII Antibody (C-8) PE | sc-376770 PE | 200 µg/ml | $349.00 | |||
Factor XII Antibody (C-8) Alexa Fluor® 488 | sc-376770 AF488 | 200 µg/ml | $364.00 | |||
Factor XII Antibody (C-8) Alexa Fluor® 546 | sc-376770 AF546 | 200 µg/ml | $364.00 | |||
Factor XII Antibody (C-8) Alexa Fluor® 594 | sc-376770 AF594 | 200 µg/ml | $364.00 | |||
Factor XII Antibody (C-8) Alexa Fluor® 647 | sc-376770 AF647 | 200 µg/ml | $364.00 | |||
Factor XII Antibody (C-8) Alexa Fluor® 680 | sc-376770 AF680 | 200 µg/ml | $364.00 | |||
Factor XII Antibody (C-8) Alexa Fluor® 790 | sc-376770 AF790 | 200 µg/ml | $364.00 |