Factor XI Antibody (G-2): sc-365996
- Factor XI Antibody (G-2) is a mouse monoclonal IgG1 κ Factor XI antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 111-186 mapping near the N-terminus of Factor XI of human origin
- Factor XI Antibody (G-2) is recommended for detection of Factor XI of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Factor XI Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Factor XI Antibody (G-2) for WB and IHC(P) applications. These reagents are now offered in bundles with Factor XI Antibody (G-2) (see ordering information below).
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Factor XI Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Factor XI protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Factor XI (G-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Coagulation Factor XI (FXI) is a glycoprotein synthesized primarily in the liver by platelets and megakaryocytes, circulating in plasma as a zymogen homodimer. Factor XI plays a crucial role in the coagulation cascade, specifically in the activation of the consolidation phase of blood coagulation through a thrombin-generated feedback loop, which is essential for effective hemostasis. Factor XI′s structure, characterized by a trypsin-like serine protease domain, is vital for enzymatic activity, allowing Factor XI to cleave and activate Factor IX, thereby amplifying the coagulation response. Factor XI has a plasma half-life of approximately 52 hours, with typical plasma concentrations around 5 mg/l. Deficiencies in Factor XI can lead to Hemophilia C, a bleeding disorder that presents a variable bleeding tendency and is inherited in an autosomal recessive manner, although heterozygotes may also experience mild bleeding symptoms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor XI Antibody (G-2) References:
- Real-time quantitative PCR analysis of factor XI mRNA variants in human platelets. | Podmore, A., et al. 2004. J Thromb Haemost. 2: 1713-9. PMID: 15456480
- Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): a cross-reactive material positive variant defective in factor IX activation. | Zivelin, A., et al. 2004. J Thromb Haemost. 2: 1782-9. PMID: 15456490
- The profibrinolytic effect of plasma thrombomodulin in factor XI deficiency and its implications in hemostasis. | Dai, L., et al. 2004. J Thromb Haemost. 2: 2200-4. PMID: 15613027
- Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling. | O'Connell, NM., et al. 2005. J Thromb Haemost. 3: 127-38. PMID: 15634276
- Plasma replacement therapy during labor is not mandatory for women with severe factor XI deficiency. | Salomon, O., et al. 2005. Blood Coagul Fibrinolysis. 16: 37-41. PMID: 15650544
- Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice. | Wang, X., et al. 2005. J Thromb Haemost. 3: 695-702. PMID: 15733058
- Co-existence of Bernard Soulier syndrome and factor XI deficiency in a family: a unified pathology? | Ghosh, K., et al. 2005. Platelets. 16: 85-9. PMID: 15823864
- Novel missense mutations in two patients with factor XI deficiency (Val271Leu and Tyr351Ser) and one patient with combined factor XI and factor IX deficiency (Phe349Val). | Jayandharan, G., et al. 2005. J Thromb Haemost. 3: 808-11. PMID: 15842381
- Coagulation factor XI: a database of mutations and polymorphisms associated with factor XI deficiency. | Dossenbach-Glaninger, A. and Hopmeier, P. 2005. Blood Coagul Fibrinolysis. 16: 231-8. PMID: 15870541
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor XI Antibody (G-2) | sc-365996 | 200 µg/ml | $322.00 | |||
Factor XI Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-527405 | 200 µg Ab; 10 µg BP | $361.00 | |||
Factor XI Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-532778 | 200 µg Ab; 20 µg BP | $361.00 | |||
Factor XI Antibody (G-2) AC | sc-365996 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Factor XI Antibody (G-2) HRP | sc-365996 HRP | 200 µg/ml | $322.00 | |||
Factor XI Antibody (G-2) FITC | sc-365996 FITC | 200 µg/ml | $336.00 | |||
Factor XI Antibody (G-2) PE | sc-365996 PE | 200 µg/ml | $349.00 | |||
Factor XI Antibody (G-2) Alexa Fluor® 488 | sc-365996 AF488 | 200 µg/ml | $364.00 | |||
Factor XI Antibody (G-2) Alexa Fluor® 546 | sc-365996 AF546 | 200 µg/ml | $364.00 | |||
Factor XI Antibody (G-2) Alexa Fluor® 594 | sc-365996 AF594 | 200 µg/ml | $364.00 | |||
Factor XI Antibody (G-2) Alexa Fluor® 647 | sc-365996 AF647 | 200 µg/ml | $364.00 | |||
Factor XI Antibody (G-2) Alexa Fluor® 680 | sc-365996 AF680 | 200 µg/ml | $364.00 | |||
Factor XI Antibody (G-2) Alexa Fluor® 790 | sc-365996 AF790 | 200 µg/ml | $364.00 |