Factor X Antibody (CaFX-50): sc-101370
- Factor X Antibody (CaFX-50) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against Factor X of human origin
- recommended for detection of the Gla-domain of Factor X of human origin by WB and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Factor X Antibody (CaFX-50) for WB applications. These reagents are now offered in bundles with Factor X Antibody (CaFX-50) (see ordering information below).
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SEE ALSO...
Factor X Antibody (CaFX-50) is a mouse monoclonal IgG1 antibody that detects Coagulation Factor X in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Factor X, also known as Stuart Prower factor, plays a crucial role in the hemostatic process following tissue injury by serving as a key component in the blood coagulation cascade. This vitamin K-dependent serine protease is synthesized in the liver and circulates as an inactive precursor until activated through cleavage by either Factor IX A or Factor VII A, resulting in the formation of active Factor X A. Coagulation Factor X (CaFX-50) monoclonal antibody forms a disulfide-linked dimer, which, in conjunction with cofactor Factor V A and calcium ions on the surface of platelets or endothelial cells, participates in the prothrombinase complex. This complex is essential for converting Prothrombin into active Thrombin, a pivotal step in fibrin clot formation and platelet aggregation promotion. Deficiencies in Factor X due to mutations at the Factor X locus can lead to serious bleeding disorders, highlighting the significance of this protein in maintaining hemostatic balance. Coagulation Factor X (CaFX-50) antibody serves as an invaluable tool for researchers studying coagulation pathways and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor X Antibody (CaFX-50) References:
- The site of activation of factor X by cancer procoagulant. | Gordon, SG. and Mourad, AM. 1991. Blood Coagul Fibrinolysis. 2: 735-9. PMID: 1799660
- The roles of cell surface attachment molecules and coagulation Factor X in adenovirus 5-mediated gene transfer in pancreatic cancer cells. | Hamdan, S., et al. 2011. Cancer Gene Ther. 18: 478-88. PMID: 21566668
- Cancer procoagulant A: a factor X activating procoagulant from malignant tissue. | Gordon, SG., et al. 1975. Thromb Res. 6: 127-37. PMID: 234638
- XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. | Chen, X., et al. 2014. Nature. 508: 103-107. PMID: 24670641
- Co-localization of Coagulation Factor X and its Inhibitory System, PZ/ZPI, in Human Endometrial Cancer Tissue. | Sierko, E., et al. 2019. In Vivo. 33: 771-776. PMID: 31028196
- Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients? | Poenou, G., et al. 2023. Int J Mol Sci. 24: PMID: 37833881
- Mammalian IRE1α dynamically and functionally coalesces with stress granules. | Liu, S., et al. 2024. Nat Cell Biol. 26: 917-931. PMID: 38714852
- Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer. | Calì, B., et al. 2024. Cancer Cell. 42: 1676-1692.e11. PMID: 39303726
- Three-stage chromogenic assay for the analysis of activation properties of factor X by cancer procoagulant. | Mielicki, WP. and Gordon, SG. 1993. Blood Coagul Fibrinolysis. 4: 441-6. PMID: 8329571
- Cancer procoagulant: a factor X activator, tumor marker and growth factor from malignant tissue. | Gordon, SG. and Mielicki, WP. 1997. Blood Coagul Fibrinolysis. 8: 73-86. PMID: 9518049
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor X Antibody (CaFX-50) | sc-101370 | 200 µg/ml | $316.00 | |||
Factor X Antibody (CaFX-50): m-IgG Fc BP-HRP Bundle | sc-539752 | 200 µg Ab; 10 µg BP | $354.00 | |||
Factor X Antibody (CaFX-50): m-IgG1 BP-HRP Bundle | sc-541685 | 200 µg Ab; 20 µg BP | $354.00 |