Factor VIII Antibody (RFFVIIIC/8): sc-59514

Factor VIII Antibody (RFFVIIIC/8) is a mouse monoclonal IgG1 antibody designed to target the full-length human purified native Factor VIII protein, also known as anti-hemophilic factor or von Willebrand factor-binding protein. Factor VIII is a crucial glycoprotein cofactor in the blood coagulation cascade, playing an essential role in the activation of Factor X to Factor Xa, which ultimately leads to the formation of stable blood clots. Anti-Factor VIII antibody (RFFVIIIC/8) effectively recognizes the 360 kDa band of Factor VIII, as well as its 210 kDa and 92 kDa fragments derived from both human and porcine sources, as demonstrated through western blotting (WB) and enzyme-linked immunosorbent assay (ELISA) assays. Factor VIII monoclonal antibody (RFFVIIIC/8) allows researchers to investigate Factor VIII synthesis, regulation, and interactions within the coagulation pathway, which is vital for understanding and addressing hemophilia A, a severe hereditary bleeding disorder caused by insufficient or dysfunctional Factor VIII. By facilitating accurate detection and quantification of Factor VIII, anti-Factor VIII antibody (RFFVIIIC/8) supports both clinical diagnostics and advanced research aimed at developing therapies and improving patient outcomes. Additionally, Factor VIII (RFFVIIIC/8) antibody′s ability to bind to multiple fragments of Factor VIII enhances research utility in studying structural and functional dynamics. Factor VIII monoclonal antibody (RFFVIIIC/8) serves as an indispensable tool for scientists and healthcare professionals dedicated to unraveling the complexities of blood coagulation and treating Factor VIII-related disorders.

The preferred Factor VIII antibody is Factor VIII Antibody (R8B12): sc-73597.