Factor VIII Antibody (GMA-8001): sc-65948

Factor VIII Antibody (GMA-8001) is a mouse monoclonal IgG1 antibody engineered to recognize the A3 domain of B domain-deleted recombinant human Factor VIII, also known as anti-hemophilic factor or von Willebrand factor-binding protein. Factor VIII is a pivotal glycoprotein cofactor in the blood coagulation cascade, essential for the activation of Factor X to Factor Xa, which ultimately leads to the formation of stable blood clots. Factor VIII antibody (GMA-8001) effectively detects human Factor VIII through enzyme-linked immunosorbent assay (ELISA), providing reliable performance for both research and diagnostic applications. Factor VIII interacts with several key proteins, including von Willebrand factor (VWF), which stabilizes Factor VIII in the bloodstream, and chaperone proteins such as Calreticulin and Calnexin in the endoplasmic reticulum, ensuring proper folding and functionality. Additionally, Factor VIII forms complexes with Factor IXa during the coagulation process, highlighting Factor VIII′s central role in maintaining hemostasis. By targeting the A3 domain, Factor VIII monoclonal antibody (GMA-8001) facilitates precise investigations into Factor VIII′s interactions and structural dynamics, which are crucial for understanding hemophilia A, a severe hereditary bleeding disorder caused by deficiencies or dysfunctions of Factor VIII. Factor VIII antibody (GMA-8001) is an indispensable tool for scientists and healthcare professionals dedicated to advancing the understanding and treatment of coagulation disorders.

The preferred Factor VIII antibody is Factor VIII Antibody (R8B12): sc-73597.