Factor VII Antibody (RFF-VII/1): sc-59506
- Factor VII Antibody (RFF-VII/1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against purified factor VII
- recommended for detection of Factor VII of human origin by ELISA; non cross-reactive with reduced Factor VII
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Factor VII Antibody (RFF-VII/1). This reagent is now offered in a bundle with Factor VII Antibody (RFF-VII/1) (see ordering information below).
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Factor VII Antibody (RFF-VII/1) is a mouse monoclonal IgG1 antibody that detects Factor VII in human samples through enzyme-linked immunosorbent assay (ELISA). Factor VII, also known as serum prothrombin conversion accelerator, proconvertin, or coagulation factor 7, is a crucial component in the hemostatic process, playing a vital role in the blood coagulation cascade. This 406 amino acid protein is synthesized in the liver and circulates as an inactive precursor until activated by proteolytic cleavage at the Arg 152-Ile 153 site, resulting in Factor VII A formation. The active form of Factor VII is a serine protease consisting of a heavy chain linked by disulfide bonds to a light chain, featuring two epidermal growth factor-like domains essential for function. Proper functioning of Factor VII is critical for initiating the coagulation cascade, as Factor VII activates Factor X, leading to thrombin generation and subsequent fibrin clot formation. Deficiencies in Factor VII can lead to bleeding disorders, although many mutations at the F7 locus may remain asymptomatic or present with mild symptoms. Anti-Factor VII antibody (RFF-VII/1) serves as an invaluable tool for researchers studying coagulation pathways and related disorders, providing insights into hemostasis mechanisms and potential therapeutic targets.
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Factor VII Antibody (RFF-VII/1) References:
- Factor VII as a marker of hepatocellular synthetic function in liver disease. | Green, G., et al. 1976. J Clin Pathol. 29: 971-5. PMID: 1002840
- Engineered recombinant factor VII Q217 variants with altered inhibitor specificities. | Chang, YJ., et al. 1999. Biochemistry. 38: 10940-8. PMID: 10460149
- Factor VII hyperactivity in chronic dialysis patients. | Kario, K., et al. 1992. Thromb Res. 67: 105-13. PMID: 1332212
- A review of recombinant factor VII for refractory bleeding in nonhemophilic trauma patients. | Barletta, JF., et al. 2005. J Trauma. 58: 646-51. PMID: 15761369
- Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolism. | Folsom, AR., et al. 2007. J Thromb Haemost. 5: 1674-8. PMID: 17663738
- Further understanding of recombinant activated factor VII mode of action. | Monroe, DM. 2008. Semin Hematol. 45: S7-S11. PMID: 18544430
- Mutations of TFPI-binding exosites on factor VII cause bleeding phenotypes in factor VII deficiency. | Seanoon, K., et al. 2022. Blood Adv. 6: 5887-5897. PMID: 35973191
- Immobilization of blood coagulant factor VII on polycaprolactone membrane through polydopamine grafting. | Gopal, R., et al. 2023. Colloids Surf B Biointerfaces. 228: 113390. PMID: 37315506
- Factor VII activation and oral contraceptives. | Plu-Bureau, G., et al. 1993. Thromb Res. 70: 275-80. PMID: 8327993
- Very low activated factor VII and reduced factor VII antigen in familial abetalipoproteinaemia. | Miller, GJ., et al. 1998. Thromb Haemost. 80: 233-8. PMID: 9716144
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor VII Antibody (RFF-VII/1) | sc-59506 | 200 µg/ml | $316.00 | |||
Factor VII Antibody (RFF-VII/1): m-IgG1 BP-HRP Bundle | sc-542606 | 200 µg Ab; 20 µg BP | $354.00 |