Exportin 5 Antibody (A-4): sc-166789
- Exportin 5 Antibody (A-4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 905-1204 mapping at the C-terminus of Exportin 5 of human origin
- recommended for detection of Exportin 5 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Exportin 5 Antibody (A-4) for WB applications. This reagent is now offered in a bundle with Exportin 5 Antibody (A-4) (see ordering information below).
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Exportin 5 Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects Exportin 5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Exportin 5 plays a crucial role in the nuclear transport of RNA, specifically recognizing and transporting RNAs that contain minihelix motifs, which are essential for the proper export of these molecules from the nucleus to the cytoplasm. This transport mechanism is vital for maintaining cellular function, as it ensures that the necessary RNA species, including those involved in protein synthesis and gene regulation, are available in the cytoplasm where they can be translated into proteins. Additionally, Exportin 5 is involved in the transport of double-stranded RNA binding proteins, such as eEF1A and tRNA, further highlighting its importance in cellular processes. Anti-Exportin 5 antibody (A-4) is an invaluable tool for researchers studying RNA transport mechanisms and their implications in various biological contexts.
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Exportin 5 Antibody (A-4) References:
- Exportin-5 orthologues are functionally divergent among species. | Shibata, S., et al. 2006. Nucleic Acids Res. 34: 4711-21. PMID: 16963774
- Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs. | Lund, E. and Dahlberg, JE. 2006. Cold Spring Harb Symp Quant Biol. 71: 59-66. PMID: 17381281
- Exportin-5 mediates nuclear export of SRP RNA in vertebrates. | Takeiwa, T., et al. 2015. Genes Cells. 20: 281-91. PMID: 25656399
- ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. | Sun, HL., et al. 2016. Cancer Cell. 30: 723-736. PMID: 27846390
- Importin-β and exportin-5 are strong biomarkers of productive reoviral infection of cancer cells. | Nuovo, G., et al. 2018. Ann Diagn Pathol. 32: 28-34. PMID: 29414394
- Structural Basis for Selective Binding of Export Cargoes by Exportin-5. | Yamazawa, R., et al. 2018. Structure. 26: 1393-1398.e2. PMID: 30100359
- An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles. | Clancy, JW., et al. 2019. Nat Cell Biol. 21: 856-866. PMID: 31235936
- Exportin-5 SUMOylation promotes hepatocellular carcinoma progression. | Lin, D., et al. 2020. Exp Cell Res. 395: 112219. PMID: 32763246
- Selectivity of Exportin 5 binding to human precursor microRNAs. | Zhang, X., et al. 2021. RNA Biol. 18: 730-737. PMID: 34592896
- Prognostic significance of exportin-5 in hepatocellular carcinoma. | Li, H., et al. 2024. World J Gastrointest Oncol. 16: 3069-3081. PMID: 39072169
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exportin 5 Antibody (A-4) | sc-166789 | 200 µg/ml | $322.00 | |||
Exportin 5 Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-542670 | 200 µg Ab; 20 µg BP | $361.00 |