Exendin 4 Antibody (ABS 012-20): sc-57119

Exendin 4 Antibody (ABS 012-20) is a mouse monoclonal IgG1 antibody that detects Exendin 4 in Heloderma suspectum by enzyme-linked immunosorbent assay (ELISA). Exendin 4 is a 39 amino acid peptide produced exclusively by the salivary glands of the Gila Monster, Heloderma suspectum, and plays a crucial role as an agonist of the Glucagon-like peptide (GLP) receptor, which is significant for anorexigenic and fat-reducing properties. Exendin 4′s importance extends beyond appetite regulation; Exendin 4 is also involved in glucose metabolism modulation, as plasma levels increase in response to feeding, indicating a function in energy homeostasis. Exendin 4 exhibits anti-apoptotic and beta cell proliferative properties, which are vital for maintaining pancreatic health and function. Exendin 4 induces phosphorylation of key signaling molecules such as Raf-1 and extracellular signal-regulated kinase (ERK), while enhancing levels of phosphorylated cAMP-response element-binding protein (CREB) and cyclin D1 gene, thereby promoting cell cycle progression. Exendin 4′s prolonged glucose-lowering action contributes to anti-diabetic effects in various animal models of type 2 diabetes, making Exendin 4 a valuable target for therapeutic interventions.