Molecular structure of Evans Blue, CAS Number: 314-13-6
Evans Blue (CAS 314-13-6)
See product citations (15)
Alternate Names:
Direct blue 53; CI 23860
Application:
Evans Blue is an inhibitor of EAAT-mediated L-glutamate uptake
CAS Number:
314-13-6
Molecular Weight:
960.83
Molecular Formula:
C34H24N6Na4O14S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Evans blue is a potent inhibitor of L-glutamate uptake into synaptic vesicles via EAAT. Evans Blue also inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). The compound is also a P2X-selective purinoceptor antagonist. Used as a dye, Evans blue reduces unwanted fluorescence due to the conjugation and auto fluorescence of structural elements in the tissue or cells.
Evans Blue (CAS 314-13-6) References
- Evans blue is a specific antagonist of the human epithelial Na+ channel delta-subunit. | Yamamura, H., et al. 2005. J Pharmacol Exp Ther. 315: 965-9. PMID: 16107516
- Evans blue nanocarriers visually demarcate margins of invasive gliomas. | Roller, BT., et al. 2015. Drug Deliv Transl Res. 5: 116-24. PMID: 25787737
- Evans Blue is not a suitable inhibitor of the epithelial sodium channel δ-subunit. | Perniss, A., et al. 2015. Biochem Biophys Res Commun. 466: 468-74. PMID: 26365349
- Evans Blue Dye: A Revisit of Its Applications in Biomedicine. | Yao, L., et al. 2018. Contrast Media Mol Imaging. 2018: 7628037. PMID: 29849513
- An Improved Evans Blue Staining Method for Consistent, Accurate Assessment of Plasmodiophora brassicae Resting Spore Viability. | Harding, MW., et al. 2019. Plant Dis. 103: 2330-2336. PMID: 31298992
- Using Evans Blue Dye to Determine Blood-Brain Barrier Integrity in Rodents. | Goldim, MPS., et al. 2019. Curr Protoc Immunol. 126: e83. PMID: 31483106
- Fluorescent retrograde double labeling: axonal branching in the ascending raphe and nigral projections. | van der Kooy, D. and Kuypers, HG. 1979. Science. 204: 873-5. PMID: 441742
- Evans blue dye: its accumulation in extracellular space in relation to endothelial cell basement membrane in normal an atherosclerotic areas of abdominal aorta. | Imai, H., et al. 1982. Arch Pathol Lab Med. 106: 186-91. PMID: 6895990
- Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter. | Roseth, S., et al. 1995. J Neurochem. 65: 96-103. PMID: 7790899
- P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue. | Wittenburg, H., et al. 1996. Naunyn Schmiedebergs Arch Pharmacol. 354: 491-7. PMID: 8897453
- Evans blue antagonizes both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates receptor desensitization. | Price, CJ. and Raymond, LA. 1996. Mol Pharmacol. 50: 1665-71. PMID: 8967991
- Differential modulation of AMPA receptor mediated currents by evans blue in postnatal rat hippocampal neurones. | Schürmann, B., et al. 1997. Br J Pharmacol. 121: 237-47. PMID: 9154333
Inhibitor of:
ATPGD1, EAAT, EAAT1, EAT-4, NTPDase8, P2X, P2X1, P2X2, P2X6, P2Y2, and VGLUT3.Activator of:
LRRC37A3, and TMEM16A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Evans Blue, 1 g | sc-203736B | 1 g | $46.00 | |||
Evans Blue, 10 g | sc-203736 | 10 g | $68.00 | |||
Evans Blue, 50 g | sc-203736A | 50 g | $260.00 |