ETEA Antibody (F-7): sc-374098
- ETEA Antibody (F-7) is a mouse monoclonal IgG1 κ ETEA antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 147-434 mapping at the C-terminus of ETEA of human origin
- ETEA Antibody (F-7) is recommended for detection of ETEA of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ETEA Antibody (F-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ETEA Antibody (F-7) for WB applications. These reagents are now offered in bundles with ETEA Antibody (F-7) (see ordering information below).
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ETEA Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects ETEA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ETEA (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ETEA, also known as UBX domain-containing protein 8 (UBXD8), is a 445-amino acid protein that plays a significant role in the pathophysiology of atopic dermatitis (AD), a chronic inflammatory skin condition characterized by eczematous lesions. ETEA is primarily located in the cytoplasm, where ETEA is involved in regulating protein degradation pathways, particularly through interaction with the ubiquitin-proteasome system. This localization is crucial because ETEA modulates the turnover of proteins essential for maintaining cellular homeostasis and immune responses. Dysregulation of these processes can lead to the persistence of inflammation seen in AD, as well as other atopic diseases such as asthma and hay fever. ETEA exhibits increased expression in T cells and eosinophils from patients with AD, suggesting a potential role in the resistance to apoptosis in these immune cells, which contributes to the chronic nature of the disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ETEA Antibody (F-7) References:
- Atopic dermatitis: new insights and opportunities for therapeutic intervention. | Leung, DY. 2000. J Allergy Clin Immunol. 105: 860-76. PMID: 10808164
- T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. | Trautmann, A., et al. 2000. J Clin Invest. 106: 25-35. PMID: 10880045
- Role of dysregulated apoptosis in atopic dermatitis. | Trautmann, A., et al. 2000. Apoptosis. 5: 425-9. PMID: 11256884
- Role of apoptosis in atopic dermatitis. | Trautmann, A., et al. 2001. Int Arch Allergy Immunol. 124: 230-2. PMID: 11306978
- Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. | Imai, Y., et al. 2002. Biochem Biophys Res Commun. 297: 1282-90. PMID: 12372427
- [Lymphocyte apoptosis in atopic dermatitis treated with transfer factor]. | García Angeles, J., et al. 2003. Rev Alerg Mex. 50: 3-7. PMID: 12822541
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ETEA Antibody (F-7) | sc-374098 | 200 µg/ml | $316.00 | |||
ETEA Antibody (F-7): m-IgG Fc BP-HRP Bundle | sc-527434 | 200 µg Ab; 10 µg BP | $354.00 | |||
ETEA Antibody (F-7): m-IgG1 BP-HRP Bundle | sc-532807 | 200 µg Ab; 20 µg BP | $354.00 | |||
ETEA Antibody (F-7) AC | sc-374098 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ETEA Antibody (F-7) HRP | sc-374098 HRP | 200 µg/ml | $316.00 | |||
ETEA Antibody (F-7) FITC | sc-374098 FITC | 200 µg/ml | $330.00 | |||
ETEA Antibody (F-7) PE | sc-374098 PE | 200 µg/ml | $343.00 | |||
ETEA Antibody (F-7) Alexa Fluor® 488 | sc-374098 AF488 | 200 µg/ml | $357.00 | |||
ETEA Antibody (F-7) Alexa Fluor® 546 | sc-374098 AF546 | 200 µg/ml | $357.00 | |||
ETEA Antibody (F-7) Alexa Fluor® 594 | sc-374098 AF594 | 200 µg/ml | $357.00 | |||
ETEA Antibody (F-7) Alexa Fluor® 647 | sc-374098 AF647 | 200 µg/ml | $357.00 | |||
ETEA Antibody (F-7) Alexa Fluor® 680 | sc-374098 AF680 | 200 µg/ml | $357.00 | |||
ETEA Antibody (F-7) Alexa Fluor® 790 | sc-374098 AF790 | 200 µg/ml | $357.00 |