Endothelin-1/EDN1/ET-1 Antibody (1C10): sc-57116
- Endothelin-1/EDN1/ET-1 Antibody (1C10) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against an N-terminus portion of ET-1 of human origin
- recommended for detection of ET-1 of human origin by ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Endothelin-1/EDN1/ET-1 Antibody (1C10). This work is in progress.
ET-1 Antibody (1C10) is a mouse monoclonal IgG1 antibody that detects endothelin-1 in human samples through enzyme-linked immunosorbent assay (ELISA). Endothelin-1 is a potent 21-amino acid vasoconstrictor peptide primarily produced by vascular endothelial cells, playing a crucial role in regulating vascular tone and blood pressure. Endothelin-1 function is vital as this peptide influences cardiovascular health, and dysregulation of endothelin-1 levels has been implicated in various pathological conditions, including hypertension and heart failure. Endothelin-1 production is tightly controlled, as this peptide is generated from a larger precursor known as big-endothelin through the action of endothelin-converting enzymes. Endothelin-1′s ability to induce vasoconstriction is mediated through interaction with specific receptor subtypes, ETA and ETB, which exhibit different affinities for the various endothelin isopeptides. Anti-endothelin-1 antibody (1C10) is an essential tool for researchers studying endothelin-1′s role in health and disease, providing insights into biological significance and potential therapeutic targets.
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Endothelin-1/EDN1/ET-1 Antibody (1C10) References:
- Endothelium-derived ET-1 and the development of renal injury. | De Miguel, C., et al. 2015. Am J Physiol Regul Integr Comp Physiol. 309: R1071-3. PMID: 25994955
- Investigating the Et-1/SphK/S1P Pathway as a Novel Approach for the Prevention of Inflammation-Induced Preterm Birth. | Giusto, K. and Ashby, CR. 2018. Curr Pharm Des. 24: 983-988. PMID: 29384055
- Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions. | Abdul, Y., et al. 2020. Can J Physiol Pharmacol. 98: 596-603. PMID: 32119570
- ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function. | Kuczmarski, AV., et al. 2021. Front Aging. 2: 727416. PMID: 35822003
- Ang II Promotes ET-1 Production by Regulating NOX2 Activity Through Transcription Factor Oct-1. | Kamhieh-Milz, J., et al. 2023. Arterioscler Thromb Vasc Biol. 43: 1429-1440. PMID: 37381986
- Aprocitentan, a dual endothelin-1 (ET-1) antagonist for treating resistant hypertension: Mechanism of action and therapeutic potential. | Xu, J., et al. 2023. Drug Discov Today. 28: 103788. PMID: 37742911
- Epidermal ET-1 signal induces activation of resting hair follicles by upregulating the PI3K/AKT pathway in the dermis. | Gao, Y., et al. 2024. FASEB J. 38: e23476. PMID: 38334392
- Lycium barbarum glycopeptide promotes neuroprotection in ET-1 mediated retinal ganglion cell degeneration. | Lakshmanan, Y., et al. 2024. J Transl Med. 22: 727. PMID: 39103918
- Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions. | Edgerton-Fulton, M., et al. 2024. Clin Sci (Lond). 138: 1009-1022. PMID: 39106080
- Ang-(1-7) and ET-1 Interplay Through Mas and ETB Receptor Interaction Defines a Novel Vasoprotective Mechanism. | Montezano, AC., et al. 2024. Hypertension.. PMID: 39633565
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Endothelin-1/EDN1/ET-1 Antibody (1C10) | sc-57116 | 100 µg/ml | $322.00 |