ESX1 Antibody (B-9): sc-365740

ESX1 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ESX1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ESX1 (B-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ESX1 plays a crucial role in embryonic development, particularly in the placenta and testis, where ESX1 is essential for proper placenta/fetus development and spermatogenesis. Notably, in human cell lines, ESX1 is characterized as a paired-like homeoprotein that undergoes proteolytic processing into N-terminal and C-terminal fragments. The N-terminal fragment, which contains the homeodomain, is localized in the nucleus and functions to repress mRNA transcription from the K-ras gene. Given that mutations in the K-ras gene are among the most prevalent genetic alterations found in human tumors, ESX1 is increasingly recognized as a potential therapeutic target for treating cancers associated with oncogenic K-ras mutations. With diverse applications and significant biological implications, anti-ESX1 antibody (B-9) serves as an invaluable tool for researchers investigating ESX1 roles in development and cancer biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ESX1 Antibody (B-9) References:

1. A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein.  |  Yan, YT., et al. 2000. Mol Cell Biol. 20: 661-71. PMID: 10611245
2. Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene.  |  Yanagihara, M., et al. 2005. Oncogene. 24: 5878-87. PMID: 15897875
3. Stage-dependent expression of extra-embryonic tissue-spermatogenesis-homeobox gene 1 (ESX1) protein, a candidate marker for X chromosome-bearing sperm.  |  Yeh, YC., et al. 2005. Reprod Fertil Dev. 17: 447-55. PMID: 15899157
4. Rapid evolution of primate ESX1, an X-linked placenta- and testis-expressed homeobox gene.  |  Wang, X. and Zhang, J. 2007. Hum Mol Genet. 16: 2053-60. PMID: 17588961
5. Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.  |  Nakajima, J., et al. 2008. Biochem Biophys Res Commun. 370: 189-94. PMID: 18361917
6. Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells.  |  Li, Y., et al. 1997. Dev Biol. 188: 85-95. PMID: 9245514
7. Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth.  |  Li, Y. and Behringer, RR. 1998. Nat Genet. 20: 309-11. PMID: 9806555

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ESX1 Antibody (B-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ESX1 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ESX1 Antibody (B-9) Specifications

Alternate Product Name: ESX1

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-184

Epitope Target: ESX1

Epitope Species: human

Product Reactivity/Detection: ESX1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ESX1 Antibody (B-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin