Esophagin Antibody (E-6): sc-514844

Esophagin Antibody (E-6) is a mouse monoclonal IgM kappa antibody that detects Esophagin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Esophagin antibody (E-6) is available as non-conjugated format. Esophagin, also known as small proline-rich protein 3 (SPR3) or Cornifin β, belongs to the cornifin family of cornified-envelope structural proteins, primarily expressed in mucosal epithelia such as the esophagus and tongue. Esophagin expression significantly increases during epidermal keratinocyte differentiation, making Esophagin (E-6) monoclonal antibody a crucial marker of squamous differentiation. Esophagin functions as a cross-linking agent in cornified cell envelope formation, contributing to structural integrity and barrier function of the epithelium. This role proves particularly important for maintaining normal esophageal epithelial homeostasis by protecting against environmental stressors. Esophagin shares significant homology with related proteins SPRR1 and SPRR2, and while Esophagin remains typically absent in healthy human epithelium, Esophagin expression increases in various hyperproliferative skin disorders. In esophageal squamous cell carcinoma, Esophagin expression dramatically decreases, highlighting Esophagin′s potential as a biomarker for disease progression and epithelial integrity.

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Esophagin Antibody (E-6) References:

1. Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein.  |  Steinert, PM., et al. 1999. Cell Death Differ. 6: 916-30. PMID: 10510474
2. Activation of the esophagin promoter during esophageal epithelial cell differentiation.  |  Smolinski, KN., et al. 2002. Genomics. 79: 875-80. PMID: 12036303
3. Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa.  |  Katou, F., et al. 2003. Br J Dermatol. 148: 898-905. PMID: 12786819
4. Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3.  |  Lehr, E., et al. 2004. J Med Virol. 72: 478-83. PMID: 14748073
5. Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression.  |  Kimos, MC., et al. 2004. Int J Cancer. 111: 415-7. PMID: 15221970
6. Enhancement of long-term memory retention by Colostrinin in one-day-old chicks trained on a weak passive avoidance learning paradigm.  |  Stewart, MG. and Banks, D. 2006. Neurobiol Learn Mem. 86: 66-71. PMID: 16473531
7. Decreased polyphenol transport across cultured intestinal cells by a salivary proline-rich protein.  |  Cai, K., et al. 2006. Biochem Pharmacol. 71: 1570-80. PMID: 16580640
8. Two-dimensional electrophoresis study of in vitro pellicle formation and dental caries susceptibility.  |  Vitorino, R., et al. 2006. Eur J Oral Sci. 114: 147-53. PMID: 16630307
9. Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis.  |  Zhang, Y., et al. 2008. Int J Cancer. 122: 260-6. PMID: 17935133

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Esophagin Antibody (E-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Esophagin Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Esophagin Antibody (E-6) Specifications

Alternate Product Name: Esophagin

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 103-152

Epitope Target: Esophagin

Epitope Species: human

Product Reactivity/Detection: Esophagin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Esophagin Antibody (E-6): N/A