ESD Antibody (6-RE43): sc-134333

ESD Antibody (6-RE43) is a mouse monoclonal IgG2a antibody that detects ESD in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ESD, also known as esterase D or S-formylglutathione hydrolase, is a 282 amino acid protein belonging to the esterase D family, primarily expressed in the placenta, kidney, liver, and erythrocytes, and is localized in the cytoplasm and cytoplasmic vesicles. ESD plays a crucial role in detoxifying formaldehyde, a harmful compound that can accumulate in the body, by catalyzing the hydrolysis of S-formylglutathione into reduced forms of formic acid and glutathione, thereby providing energy and protecting cells from oxidative stress. Additionally, ESD is capable of hydrolyzing various neutral ester substrates and may function as a carboxylesterase, contributing to metabolic processes. Importantly, polymorphisms in the ESD gene can lead to reduced enzymatic activity, which has been associated with an increased risk of conditions such as toxic liver cirrhosis, retinoblastoma, obesity, and autism, highlighting ESD′s significance in human health. Anti-ESD antibody (6-RE43) is an essential tool for researchers investigating the biochemical pathways involving formaldehyde detoxification and the implications of ESD in various diseases.

The preferred ESD antibody is ESD Antibody (A-5): sc-514892.