ERRα Antibody (1ERR87): sc-65715
- ERRα Antibody (1ERR87) is a mouse monoclonal IgG1 κ, cited in 10 publications, provided at 200 µg/ml
- raised against amino acids 1-76 of ERRα of human origin
- recommended for detection of ERRα of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG1 BP-HRP is the preferred secondary detection reagent for ERRα Antibody (1ERR87) for WB and IHC(P) applications. This reagent is now offered in a bundle with ERRα Antibody (1ERR87) (see ordering information below).
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ERRα Antibody (1ERR87) is a mouse monoclonal IgG1 antibody that detects ERRα in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. ERRα, or estrogen-related receptor alpha, is a crucial nuclear receptor that belongs to the superfamily of ligand-regulated transcription factors and is part of the NR3B orphan nuclear receptor subgroup. ERRα plays a significant role in modulating the estrogen signaling pathway and is particularly important for regulating mitochondrial biogenesis and oxidative metabolism, as ERRα directly influences the expression of genes essential for mitochondrial function. Notably, ERRα expression increases during fasting and cold exposure, highlighting ERRα′s role in energy homeostasis and thermoregulation; mice lacking ERRα struggle to maintain body temperature in cold environments. Furthermore, ERRα is implicated in the maintenance and formation of cartilage, making ERRα a potential target for therapeutic interventions in joint-related diseases. Anti-ERRα antibody (1ERR87) is an invaluable tool for researchers investigating the multifaceted roles of ERRα in various biological processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ERRα Antibody (1ERR87) References:
- Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. | Pan, Z., et al. 2022. Mol Cancer. 21: 77. PMID: 35303882
- Targeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation. | Seo, W., et al. 2022. J Hematol Oncol. 15: 156. PMID: 36289517
- Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRα-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats. | Li, M., et al. 2023. Redox Biol. 61: 102649. PMID: 36871183
- Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. | Billon, C., et al. 2023. ACS Chem Biol. 18: 756-771. PMID: 36988910
- ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer. | Su, P., et al. 2023. J Exp Clin Cancer Res. 42: 274. PMID: 37864196
- Identification of a chromatin-bound ERRα interactome network in mouse liver. | Scholtes, C., et al. 2024. Mol Metab. 83: 101925. PMID: 38537884
- Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression. | Desmet, SJ., et al. 2024. Mol Metab. 84: 101938. PMID: 38631478
- ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis. | Tian, Z., et al. 2024. J Hazard Mater. 471: 134331. PMID: 38677116
- APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling. | Ning, Z., et al. 2024. Cell Mol Biol Lett. 29: 87. PMID: 38867189
- RBBP6-Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease. | Hu, H., et al. 2024. Adv Sci (Weinh). 11: e2405153. PMID: 39441040
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERRα Antibody (1ERR87) | sc-65715 | 200 µg/ml | $322.00 | |||
ERRα Antibody (1ERR87): m-IgG1 BP-HRP Bundle | sc-542609 | 200 µg Ab; 20 µg BP | $361.00 |