ERp5 Antibody (F-5): sc-376390
- ERp5 Antibody (F-5) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 192-440 mapping at the C-terminus of ERp5 of human origin
- recommended for detection of ERp5 of mouse, rat and human origin by WB, IP, IF and ELISA
- See ERp5 (G-5): sc-365260 for ERp5 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for ERp5 Antibody (F-5) for WB applications. This reagent is now offered in a bundle with ERp5 Antibody (F-5) (see ordering information below).
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ERp5 Antibody (F-5) is a mouse monoclonal IgG2a antibody that detects ERp5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERp5, also known as PDIA6 or TXNDC7, is a 440 amino acid protein that plays a crucial role in the endoplasmic reticulum by facilitating the formation and rearrangement of disulfide bonds in nascent proteins, which is essential for proper protein folding and stability. This function is particularly important as misfolded proteins can lead to cellular stress and contribute to various diseases, including neurodegenerative disorders and cancer. ERp5 is localized not only in the endoplasmic reticulum but also in melanosomes, where ERp5 is involved in the regulation of proteins that affect pigmentation and immune responses. ERp5′s ability to reduce disulfide bonds, such as those binding MICA to tumor cells, highlights ERp5′s potential role in modulating immune responses against tumors, thereby influencing tumor progression. Additionally, multiple isoforms of ERp5 arise from alternative splicing, which may contribute to ERp5′s diverse functional roles in different cellular contexts. Anti-ERp5 antibody (F-5) is an invaluable tool for researchers studying protein folding, cellular stress responses, and the intricate mechanisms of tumor immunity.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERp5 Antibody (F-5) | sc-376390 | 200 µg/ml | $322.00 | |||
ERp5 Antibody (F-5): m-IgG2a BP-HRP Bundle | sc-552042 | 200 µg Ab; 10 µg BP | $361.00 |