ERM Antibody (H-06): sc-100941

ERM Antibody (H-06) is a mouse monoclonal IgG1 kappa light chain antibody that detects ERM protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ERM antibody (H-06) is available as the non-conjugated form. ERM protein plays a crucial role in cellular signaling and cytoskeletal organization, acting as a key regulator of cell shape and motility. ERM protein is primarily located in the cytoplasm and is involved in the formation of cell-cell junctions, which are essential for maintaining tissue integrity and facilitating communication between cells. Proper functioning of ERM protein is vital for processes such as cell adhesion, migration, and response to extracellular signals, making ERM protein an important player in development and wound healing. ERM protein interacts with various proteins, including the ezrin, radixin, and moesin family, which link the cytoskeleton to the plasma membrane, further emphasizing ERM protein′s significance in cellular architecture and signaling pathways. Using anti-ERM antibody (H-06) in research can provide valuable insights into the dynamics of cell behavior and underlying mechanisms of various physiological and pathological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ERM Antibody (H-06) References:

1. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.  |  Xin, JH., et al. 1992. Genes Dev. 6: 481-96. PMID: 1547944
2. Biochemical properties and cellular localisation of STIM proteins.  |  Dziadek, MA. and Johnstone, LS. 2007. Cell Calcium. 42: 123-32. PMID: 17382385
3. ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines.  |  Kathuria, H., et al. 2007. J Cell Biochem. 102: 13-27. PMID: 17390339
4. Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1.  |  Fisher, CL., et al. 1991. J Immunol. 146: 1743-9. PMID: 1900874
5. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.  |  Rao, VN., et al. 1989. Science. 244: 66-70. PMID: 2539641
6. ERM proteins in cancer progression.  |  Clucas, J. and Valderrama, F. 2015. J Cell Sci. 128: 1253. PMID: 25774052
7. Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.  |  Ghysdael, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 1714-8. PMID: 3006066
8. ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.  |  García-Ortiz, A. and Serrador, JM. 2020. Int J Mol Sci. 21: PMID: 32098334
9. The erg gene: a human gene related to the ets oncogene.  |  Reddy, ES., et al. 1987. Proc Natl Acad Sci U S A. 84: 6131-5. PMID: 3476934
10. PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway.  |  Zhao, L., et al. 2023. Int Immunopharmacol. 124: 110992. PMID: 37806106
11. A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.  |  Jeon, IS., et al. 1995. Oncogene. 10: 1229-34. PMID: 7700648
12. Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.  |  Monté, D., et al. 1994. Oncogene. 9: 1397-406. PMID: 8152800

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ERM Antibody (H-06) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-ERM Antibody (H-06) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ERM Antibody (H-06) Specifications

Alternate Product Name: ETV5

Product Clone Name: H-06

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 181-291

Epitope Target: ERM

Epitope Species: human

Product Reactivity/Detection: ERM

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for ERM Antibody (H-06): N/A