ERCC1 Antibody (A-2): sc-515258
- ERCC1 Antibody (A-2) is a mouse monoclonal IgG2a provided at 200 µg/ml
- specific for an epitope mapping between amino acids 15-34 within an internal region of ERCC1 of human origin
- recommended for detection of ERCC1 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-515258 X, 200 µg/0.1 ml)
- See ERCC1 (D-10): sc-17809 for ERCC1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERCC1 Antibody (A-2). This work is in progress.
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SEE ALSO...
ERCC1 Antibody (A-2) is a mouse monoclonal IgG2a antibody that detects ERCC1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERCC1 plays a crucial role in the DNA repair process, particularly in nucleotide excision repair, where ERCC1 forms a complex with the XPF protein, also known as ERCC4 or ERCC11. This complex is essential for the proper functioning of the structure-specific endonuclease that performs 5′ incisions during DNA repair, thereby facilitating the removal of damaged DNA segments. ERCC1′s importance lies in maintaining genomic stability and preventing mutations that could lead to conditions such as xeroderma pigmentosum, a disorder characterized by heightened sensitivity to UV radiation and an increased risk of skin cancer. By understanding ERCC1′s function and interactions within the DNA repair machinery, researchers can gain insights into the mechanisms of DNA damage response and potential therapeutic targets for enhancing DNA repair in various diseases. Anti-ERCC1 antibody (A-2) serves as an invaluable tool for studying these critical processes in human cells.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERCC1 Antibody (A-2) | sc-515258 | 200 µg/ml | $316.00 | |||
ERCC1 (A-2) Neutralizing Peptide | sc-515258 P | 100 µg/0.5 ml | $68.00 | |||
ERCC1 Antibody (A-2) X | sc-515258 X | 200 µg/0.1 ml | $316.00 |