ERCC1 Antibody (8F1): sc-56673
- ERCC1 Antibody (8F1) is a mouse monoclonal IgG2b, cited in 12 publications, provided at 50 µg/0.5 ml
- raised against full length ERCC1 of human origin
- recommended for detection of ERCC1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See ERCC1 (D-10): sc-17809 for ERCC1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERCC1 Antibody (8F1). This work is in progress.
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SEE ALSO...
ERCC1 Antibody (8F1) is a mouse monoclonal IgG2b antibody that detects ERCC1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERCC1 plays a crucial role in DNA repair, specifically in nucleotide excision repair, where ERCC1 partners with XPF protein to form a complex essential for proper incision of damaged DNA. The ERCC1-XPF complex recognizes and excises bulky DNA adducts, which can arise from environmental factors such as UV radiation and chemical exposure. Deficiencies in this repair mechanism can lead to severe consequences, including increased susceptibility to skin cancers, as seen in conditions like xeroderma pigmentosum. ERCC1′s ability to localize to sites of DNA damage underscores ERCC1′s importance in maintaining genomic stability and preventing mutations that could lead to tumorigenesis. Anti-ERCC1 antibody (8F1) serves as an invaluable tool for researchers studying DNA repair mechanisms and their implications in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERCC1 Antibody (8F1) | sc-56673 | 50 µg/0.5 ml | $322.00 |