ErbB4/HER4 Antibody (A-5): sc-514327

ErbB-4 Antibody (A-5) is a mouse monoclonal IgM antibody that detects ErbB-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ErbB-4 is a member of the epidermal growth factor receptor family, which plays a crucial role in cell signaling pathways that regulate cell proliferation and differentiation. ErbB-4 is primarily located on the cell membrane, where ErbB-4 can form homodimers or heterodimers upon ligand binding, a process essential for activation and subsequent signaling. ErbB-4′s membrane localization enables interaction with various ligands, such as heregulin, which promotes proteolytic cleavage, resulting in ectodomain release and activation of downstream signaling cascades. These pathways are vital for normal cellular functions and are often dysregulated in various cancers, particularly breast carcinoma, where ErbB-4 expression is notably high. Anti-ErbB-4 antibody (A-5) is an invaluable tool for researchers studying this receptor in cancer biology and therapeutic interventions.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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ErbB4/HER4 Antibody (A-5) References:

1. Immunohistochemical detection of erbB-4 expression in extramammary Paget's disease.  |  Imakado, S., et al. 1999. Acta Derm Venereol. 79: 172. PMID: 10228651
2. Expression of c-erbB-4/HER4 is regulated in T47D breast carcinoma cells by retinoids and vitamin D3.  |  Offterdinger, M., et al. 1999. Biochem Biophys Res Commun. 258: 559-64. PMID: 10383375
3. Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer.  |  Gilmour, LM., et al. 2001. Cancer Res. 61: 2169-76. PMID: 11280782
4. Type 1 growth factor receptor expression in node positive breast cancer: adverse prognostic significance of c-erbB-4.  |  Lodge, AJ., et al. 2003. J Clin Pathol. 56: 300-4. PMID: 12663644
5. Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression.  |  Merimsky, O., et al. 2003. Oncol Rep. 10: 1593-9. PMID: 12883746
6. Localization of the human HER4/erbB-4 gene to chromosome 2.  |  Zimonjic, DB., et al. 1995. Oncogene. 10: 1235-7. PMID: 7700649
7. The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.  |  Riese, DJ., et al. 1996. J Biol Chem. 271: 20047-52. PMID: 8702723
8. Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism.  |  Vecchi, M. and Carpenter, G. 1997. J Cell Biol. 139: 995-1003. PMID: 9362517
9. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.  |  Srinivasan, R., et al. 1998. J Pathol. 185: 236-45. PMID: 9771476
10. Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes.  |  Altenschmidt, U., et al. 1996. Clin Cancer Res. 2: 1001-8. PMID: 9816261

The preferred ErbB4/HER4 antibody is ErbB4/HER4 Antibody (C-7): sc-8050.