EphA3 Antibody (D-2): sc-514209

EphA3 Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects EphA3 protein of mouse, rat, human, and chicken origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-EphA3 antibody (D-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EphA3 plays a crucial role in cell signaling and communication, particularly in central nervous system development, where EphA3 is involved in processes such as neuronal guidance and synaptic plasticity. EphA3′s ability to interact with ephrin ligands, such as ephrin-A4, highlights EphA3′s importance in mediating cell-cell interactions essential for proper neural development and function. EphA3 receptor is part of the larger Eph receptor family, which is the most extensive group of receptor protein tyrosine kinases identified to date, and understanding EphA3′s function can provide insights into various developmental disorders and potential therapeutic targets.

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EphA3 Antibody (D-2) References:

1. EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma.  |  Offenhäuser, C., et al. 2018. Cancers (Basel). 10: PMID: 30562956
2. EphA3 promotes the proliferation of NPC cells through negatively regulating the ability of FOG2.  |  Song, Z., et al. 2020. Eur Rev Med Pharmacol Sci. 24: 6735-6743. PMID: 32633364
3. EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer.  |  Kim, SH., et al. 2021. Biomolecules. 11: PMID: 33919657
4. The Hippo effector YAP1/TEAD1 regulates EPHA3 expression to control cell contact and motility.  |  Al-Mathkour, MM., et al. 2022. Sci Rep. 12: 3840. PMID: 35264657
5. EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways.  |  Ming, D. and Ma, J. 2022. Open Med (Wars). 17: 2098-2108. PMID: 36578556
6. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases.  |  Cheng, HJ. and Flanagan, JG. 1994. Cell. 79: 157-68. PMID: 7522971
7. Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.  |  Bennett, BD., et al. 1995. Proc Natl Acad Sci U S A. 92: 1866-70. PMID: 7534404
8. Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.  |  Valenzuela, DM., et al. 1995. Oncogene. 10: 1573-80. PMID: 7731712
9. Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system.  |  Ciossek, T., et al. 1995. Oncogene. 10: 97-108. PMID: 7824284
10. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.  |  Kozlosky, CJ., et al. 1995. Oncogene. 10: 299-306. PMID: 7838529
11. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.  |  Fox, GM., et al. 1995. Oncogene. 10: 897-905. PMID: 7898931
12. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.  |  Beckmann, MP., et al. 1994. EMBO J. 13: 3757-62. PMID: 8070404

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EphA3 Antibody (D-2) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-EphA3 Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EphA3 Antibody (D-2) Specifications

Alternate Product Name: EphA3

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 31-54

Epitope Target: EphA3

Epitope Species: human

Product Reactivity/Detection: EphA3

Species Reactivity/Detection: mouse, rat, human, chicken

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for EphA3 Antibody (D-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin