Ep-CAM Antibody (G8.8): sc-53532
- Ep-CAM Antibody (G8.8) is a rat monoclonal IgG2a, cited in 29 publications, provided at 200 µg/ml
- raised against TE-71 medullary thymic epithelial cell line of mouse origin
- Ep-CAM Antibody (G8.8) is recommended for detection of Ep-CAM of mouse origin by WB, IP, IF and IHC(P)
- Anti-Ep-CAM Antibody (G8.8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ep-CAM Antibody (G8.8). This work is in progress.
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SEE ALSO...
Ep-CAM Antibody (G8.8) is a rat monoclonal IgG2a antibody that detects Ep-CAM protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ep-CAM (G8.8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. The epithelial cell adhesion molecule, also known as tumor-associated calcium signal transducer 1 and MK-1, plays a crucial role in cell-cell adhesion and is predominantly expressed in normal epithelial tissues as well as in various carcinomas. Ep-CAM protein is located on the cell membrane, where Ep-CAM facilitates the adhesion of epithelial cells, which is vital for maintaining tissue integrity and function. Notably, aberrant expression of Ep-CAM is associated with tumor progression and metastasis, making Ep-CAM a significant biomarker for cancer diagnosis and a potential therapeutic target. The human Ep-CAM gene encodes a 314 amino acid protein that exists in two forms, with the major form being more prevalent; this expression can be modulated by glycosylation processes, such as those inhibited by tunicamycin. The structure of Ep-CAM includes an extracellular domain with two epidermal growth factor-like repeats, followed by a cysteine-poor region essential for its adhesive properties, underscoring Ep-CAM′s importance in both normal physiology and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ep-CAM Antibody (G8.8) | sc-53532 | 200 µg/ml | $322.00 | |||
Ep-CAM Antibody (G8.8) AC | sc-53532 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Ep-CAM Antibody (G8.8) HRP | sc-53532 HRP | 200 µg/ml | $322.00 | |||
Ep-CAM Antibody (G8.8) FITC | sc-53532 FITC | 200 µg/ml | $336.00 | |||
Ep-CAM Antibody (G8.8) PE | sc-53532 PE | 200 µg/ml | $349.00 | |||
Ep-CAM Antibody (G8.8) Alexa Fluor® 488 | sc-53532 AF488 | 200 µg/ml | $364.00 | |||
Ep-CAM Antibody (G8.8) Alexa Fluor® 546 | sc-53532 AF546 | 200 µg/ml | $364.00 | |||
Ep-CAM Antibody (G8.8) Alexa Fluor® 594 | sc-53532 AF594 | 200 µg/ml | $364.00 | |||
Ep-CAM Antibody (G8.8) Alexa Fluor® 647 | sc-53532 AF647 | 200 µg/ml | $364.00 | |||
Ep-CAM Antibody (G8.8) Alexa Fluor® 680 | sc-53532 AF680 | 200 µg/ml | $364.00 | |||
Ep-CAM Antibody (G8.8) Alexa Fluor® 790 | sc-53532 AF790 | 200 µg/ml | $364.00 |