Date published: 2025-9-5
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EOMES Antibody (1A8) - Western Blotting - Image 352164
EOMES 抗体 (1A8): sc-293481. IMR-32 全细胞裂解液中 EOMES 表达的 Western 印迹分析.
EOMES Antibody (1A8) - Western Blotting - Image 352164
EOMES 抗体 (1A8): sc-293481. IMR-32 全细胞裂解液中 EOMES 表达的 Western 印迹分析.
EOMES 抗体 (1A8): sc-293481. IMR-32 全细胞裂解液中 EOMES 表达的 Western 印迹分析.

EOMES 抗体 (1A8): sc-293481

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说明书
  • EOMES 抗体 1A8 是小鼠单克隆 IgG2a κ，EOMES抗体, 在2篇文献中引用，规格为100 µg/ml
  • 免疫human物种的代表全长EOMES的氨基酸461-569
  • 推荐用于 mouse, rat 和 human 来源的EOMES WB, IP 和 ELISA检测
  • 关于如何获取EOMES (1A8): sc-293481的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是EOMES Antibody (1A8) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与EOMES Antibody (1A8) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

EOMES抗体（1A8）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的EOMES蛋白。抗EOMES抗体（1A8）以非结合形式提供。EOMES或eomesodermin同源物是一种关键的转录因子，在人类中由686个氨基酸组成，与小鼠Eomes蛋白具有同源性，并具有单个T-box DNA结合结构域。EOMES在发育过程的调节中起着至关重要的作用，特别是在发育中的大脑中，EOMES定位于细胞核。EOMES对于神经元的迁移和分裂至关重要，对滋养层细胞发育和胚泡形成过程有重大贡献。EOMES的正常运作至关重要，因为EOMES的沉默会导致严重的发育问题，包括以头围减少和脑畸形为特征的小头畸形。了解EOMES在这些过程中的作用，有助于我们认识EOMES在正常发育中的重要性，以及EOMES失调对各种神经系统疾病的影响。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

EOMES 抗体 (1A8) 参考文献:

  1. 在小鼠发育中的大脑中表达的一种新型哺乳动物含 T-box 的基因 Tbr2。  |  Kimura, N., et al. 1999. Brain Res Dev Brain Res. 115: 183-93. PMID: 10407135
  2. 小鼠滋养细胞的发育和中胚层的形成需要表皮生长因子。  |  Russ, AP., et al. 2000. Nature. 404: 95-9. PMID: 10716450
  3. 小鼠 Tbr2 基因的基因组结构, 序列和染色体定域以及与 Tbr1 的比较研究。  |  Ueno, M., et al. 2000. Gene. 254: 29-35. PMID: 10974533
  4. 转录因子 Eomesodermin 控制效应 CD8+ T 细胞功能。  |  Pearce, EL., et al. 2003. Science. 302: 1041-3. PMID: 14605368
  5. 效应和记忆 CD8+ T 细胞的命运由 T-bet 和 eomesodermin 触发。  |  Intlekofer, AM., et al. 2005. Nat Immunol. 6: 1236-44. PMID: 16273099
  6. T-盒转录因子EOMES的同基因沉默会导致小头畸形，并伴有多畸形和胼胝体发育不全。  |  Baala, L., et al. 2007. Nat Genet. 39: 454-6. PMID: 17353897
  7. 原发性和转移性肿瘤中克隆扩增的 EOMES+ Tr1 样细胞与疾病进展有关。  |  Bonnal, RJP., et al. 2021. Nat Immunol. 22: 735-745. PMID: 34017124
  8. 小肠和结肠组织特异性记忆CD8+ T细胞表现出分子异质性和对Eomes的不同依赖性。  |  Lin, YH., et al. 2023. Immunity. 56: 207-223.e8. PMID: 36580919
  9. 表达Eomesodermin-1型调节（EOMES+ Tr1）的T细胞：基本生物学和在免疫介导疾病中的作用。  |  Geginat, J., et al. 2023. Eur J Immunol. 53: e2149775. PMID: 36653901
  10. Eomes依赖性线粒体调节可促进炎症期间致病性CD4+ T细胞的存活。  |  Joulia, E., et al. 2024. J Exp Med. 221: PMID: 38189779
  11. Eomes表达可识别早期骨髓前体细胞，从而形成经典NK细胞。  |  Liang, Z., et al. 2024. Nat Immunol. 25: 1172-1182. PMID: 38871999
  12. T-box 基因家族四个新人类成员的鉴定, 绘图和系统进化分析：EOMES, TBX6, TBX18 和 TBX19。  |  Yi, CH., et al. 1999. Genomics. 55: 10-20. PMID: 9888994

订购信息

产品名称产品编号规格价格数量收藏夹

EOMES 抗体 (1A8)

sc-293481
100 µg/ml
$316.00

EOMES (1A8): m-IgG Fc BP-HRP 套装

sc-537752
100 µg Ab; 10 µg BP
$354.00

EOMES (1A8): m-IgGκ BP-HRP 套装

sc-535118
100 µg Ab; 40 µg BP
$354.00

EOMES (1A8): m-IgG2a BP-HRP 套装

sc-548109
100 µg Ab; 10 µg BP
$354.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with EOMES (1A8): sc-293481 antibody?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good for Western BlotAntibody works for Western blot with human and chimpanzee induced pluripotent stem cells (iPSCs) after 3-5 days of hpIPC differentiation in published research. -SCBT QC
Date published: 2023-09-14
Rated 1 out of 5 by from Not good for IHCThis is a great antibody for western blotting on mouse brain tissue, but not for immunohistochemistry.
Date published: 2018-07-19
Rated 5 out of 5 by from Works for human NPCsWorked well with direct immunofluorescence staining of PFA-fixed differentiated hNPCs, 1:200 dilution fator
Date published: 2018-06-06
Rated 1 out of 5 by from Not for mice/rat IHCI tried this antibody for IHC using free-floating sections from postnatal mice and rat brain (both P1 and P6). Both standard and antigen-retrieval protocols were used. No positive staining was detected.
Date published: 2018-03-26
Rated 5 out of 5 by from Eomes抗体ChIP很给力用了该公司Eomes抗体的试用装来做ChIP，根据已经报道的靶基因设计引物，跑PCR，拉出来的条带还是蛮给力的
Date published: 2017-11-30
Rated 5 out of 5 by from Great antibodyTested on E14.5 mouse brain on western blotting. It is great antibody and only a single band is observed at 73 Kda. I use 1:1000 over night at 4 C.
Date published: 2017-07-13
Rated 5 out of 5 by from Great antibodyI used this antibody on E14.5 mouse brain, and it is great! Only a single band appeared on the size described in data sheet. I used 1:000 dilution for the primary and 1:2000 for the secondary antibody. I strongly recommended.
Date published: 2017-04-25
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EOMES 抗体 (1A8) is rated 3.9 out of 5 by 7.
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