ENX-1 Antibody (C-1): sc-166609

ENX-1 Antibody (C-1) is a mouse monoclonal IgG2b antibody that detects ENX-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ENX-1, a member of the Polycomb group (PcG) gene family, plays a crucial role in regulating gene expression during embryonic development by repressing homeotic loci, which is essential for proper body plan formation. ENX-1 is predominantly expressed during early embryogenesis and later becomes localized to the central and peripheral nervous systems, as well as sites of fetal hematopoiesis, highlighting ENX-1′s importance in both developmental and adult tissue contexts. The human ENX-1 gene encodes a 746 amino acid polypeptide featuring a trithorax-like domain and a DNA-binding motif, which are critical for ENX-1′s function in gene regulation. ENX-1 interacts with the proto-oncogene product Vav, suggesting involvement in the proliferation of both normal and malignant hematopoietic cells. Alterations in the regulation of target genes by ENX-1 may contribute to specific phenotypes associated with Down syndrome, underscoring ENX-1′s significance in both health and disease.

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ENX-1 Antibody (C-1) References:

1. Proliferative involvement of ENX-1, a putative human polycomb group gene, in haematopoietic cells.  |  Fukuyama, T., et al. 2000. Br J Haematol. 108: 842-7. PMID: 10792293
2. Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.  |  Orzan, F., et al. 2011. Neuropathol Appl Neurobiol. 37: 381-94. PMID: 20946108
3. Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability.  |  Wu, SC. and Zhang, Y. 2011. J Biol Chem. 286: 28511-9. PMID: 21659531
4. Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.  |  Friedman, J., et al. 2011. J Virol. 85: 9078-89. PMID: 21715480
5. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer.  |  Ding, M., et al. 2015. Clin Exp Pharmacol Physiol. 42: 458-64. PMID: 25739318
6. Enhancer of zeste 2 polycomb repressive complex 2 subunit promotes sorafenib resistance of hepatocellular carcinoma though insulin-like growth factor 1 receptor.  |  Hu, J., et al. 2019. Anticancer Drugs. 30: e0746. PMID: 31305292
7. Long noncoding RNA ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 antisense RNA 1 recruits enhancer of zeste 2 polycomb repressive complex 2 subunit to promote the proliferation, migration and invasion of lung adenocarcinoma cells.  |  Liu, J., et al. 2022. Bioengineered. 13: 7868-7880. PMID: 35291911
8. LncRNA DS Cell Adhesion Molecule Antisense RNA 1 Facilitates Oral Squamous Cell Carcinoma Progression through The microRNA-138-5p/ Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Axis.  |  Zhang, Y., et al. 2022. Cell J. 24: 222-229. PMID: 35717565
9. Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.  |  Hobert, O., et al. 1996. Mol Cell Biol. 16: 3066-73. PMID: 8649418
10. Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene.  |  Hobert, O., et al. 1996. Mech Dev. 55: 171-84. PMID: 8861097

The preferred ENX-1 antibody is ENX-1 Antibody (D-8): sc-137255.