Endophilin I Antibody (4D12): sc-134329
- Endophilin I Antibody (4D12) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant Endophilin I protein of human origin
- recommended for detection of Endophilin I of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Endophilin I Antibody (4D12). This work is in progress.
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Endophilin I Antibody (4D12) is a mouse monoclonal IgG2a antibody that detects Endophilin I in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Endophilin I plays a crucial role in the regulation of synaptic vesicle trafficking at nerve terminals, which is essential for proper neurotransmission and communication between neurons. Endophilin I is primarily localized in the brain, where anti-Endophilin I antibody (4D12) can detect its involvement in the modulation of G protein-coupled receptor signaling by acting as an adapter protein that directs β1 adrenergic receptors to the endocytic machinery, thereby influencing receptor recycling and availability at the synapse. The interaction of Endophilin I with other proteins such as Amphiphysin, Synaptojanin, and Dynamin highlights its importance in the complex processes of synaptic function and plasticity. Endophilin I monoclonal antibody (4D12) enables researchers to gain valuable insights into the mechanisms underlying synaptic transmission and the potential implications of dysregulation in neurological disorders.
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Endophilin I Antibody (4D12) References:
- Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. | Schmidt, A., et al. 1999. Nature. 401: 133-41. PMID: 10490020
- Differential expression of endophilin 1 and 2 dimers at central nervous system synapses. | Ringstad, N., et al. 2001. J Biol Chem. 276: 40424-30. PMID: 11518713
- Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. | Anggono, V. and Robinson, PJ. 2007. J Neurochem. 102: 931-43. PMID: 17437541
- Structure-based characterization of the binding of peptide to the human endophilin-1 Src homology 3 domain using position-dependent noncovalent potential analysis. | Fu, C., et al. 2012. J Mol Model. 18: 2153-61. PMID: 21947444
- Proteome-wide inference of human endophilin 1-binding peptides. | Wu, G., et al. 2012. Protein Pept Lett. 19: 1094-102. PMID: 22512650
- Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway. | Liu, W., et al. 2014. Brain Res. 1573: 17-26. PMID: 24854121
- Endophilin-1 regulates blood-brain barrier permeability via EGFR-JNK signaling pathway. | Chen, L., et al. 2015. Brain Res. 1606: 44-53. PMID: 25721793
- MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1. | Liu, W., et al. 2016. Exp Cell Res. 343: 248-257. PMID: 27038654
- The role of LINC00094/miR-224-5p (miR-497-5p)/Endophilin-1 axis in Memantine mediated protective effects on blood-brain barrier in AD microenvironment. | Zhu, L., et al. 2019. J Cell Mol Med. 23: 3280-3292. PMID: 30801976
- Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β. | Yin, Y., et al. 2019. Mol Med Rep. 19: 4897-4905. PMID: 31059028
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Endophilin I Antibody (4D12) | sc-134329 | 100 µg/ml | $333.00 |